4-(4-hydroxyphenyl)butyric acid tert-butyldimethylsilyl ester | 211857-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(4-hydroxyphenyl)butyric acid tert-butyldimethylsilyl ester
• CAS: 211857-76-0
• 化学式: C₁₆H₂₆O₃Si
• 分子量: 294.466
• InChiKey: VMISAXKZNGRSON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.26
• 重原子数：
  20.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-(4-hydroxyphenyl)butyric acid tert-butyldimethylsilyl ester 在 盐酸 、 sodium hydride 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.5h， 生成 4-[4-(Diethoxy-thiophosphoryloxy)-phenyl]-butyric acid
  参考文献：
  名称：

  Development and Evaluation of Antisera for Detection of the O,O-Diethyl Phosphorothionate and Phosphorothionothiolate Organophosphorus Pesticides by Immunoassay

  摘要：

  An immunochemical approach for class detection of organophosphorus pesticides was investigated. Synthesis of O,O-diethyl phosphorothionate haptens and their use in the generation of polyclonal antisera are described. An indirect inhibition format ELISA coupled with an automated screening procedure was used to characterize the dose-response of the resulting antisera for 17 representative O,O-diethyl and O,O-dimethyl phosphorothionates/thionothiolates and phosphates.

  DOI：

  10.1021/jf970191y
• 作为产物：
  描述：

  4-(4-甲氧基苯基)丁酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 N-甲基吗啉 、 氢溴酸 作用下， 以 四氢呋喃 为溶剂， 反应 4.5h， 生成 4-(4-hydroxyphenyl)butyric acid tert-butyldimethylsilyl ester
  参考文献：
  名称：

  Development and Evaluation of Antisera for Detection of the O,O-Diethyl Phosphorothionate and Phosphorothionothiolate Organophosphorus Pesticides by Immunoassay

  摘要：

  An immunochemical approach for class detection of organophosphorus pesticides was investigated. Synthesis of O,O-diethyl phosphorothionate haptens and their use in the generation of polyclonal antisera are described. An indirect inhibition format ELISA coupled with an automated screening procedure was used to characterize the dose-response of the resulting antisera for 17 representative O,O-diethyl and O,O-dimethyl phosphorothionates/thionothiolates and phosphates.

  DOI：

  10.1021/jf970191y