(3S,4R,7S)-7-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-3-(dimethyl-phenyl-silanyl)-7-methyl-non-1-en-4-ol | 327628-38-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,4R,7S)-7-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-3-(dimethyl-phenyl-silanyl)-7-methyl-non-1-en-4-ol
• 英文别名: (3S,4R,7S)-9-[tert-butyl(dimethyl)silyl]oxy-3-[dimethyl(phenyl)silyl]-7-methyl-7-phenylmethoxynon-1-en-4-ol
• CAS: 327628-38-6
• 化学式: C₃₁H₅₀O₃Si₂
• 分子量: 526.907
• InChiKey: KNPJJRRPGGDNGZ-HZFRXHCASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.69
• 重原子数：
  36
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4S)-6-[tert-butyl(dimethyl)silyl]oxy-4-methyl-4-phenylmethoxyhexanal 、 [(E)-γ-(dimethylphenylsilyl)allyl]diisopinocamphenylborane 在 双氧水 、 sodium sulfite 作用下， 以 四氢呋喃 、 phosphate buffer 为溶剂， 生成 (3R,4S,7S)-7-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-3-(dimethyl-phenyl-silanyl)-7-methyl-non-1-en-4-ol 、 (3S,4R,7S)-7-Benzyloxy-9-(tert-butyl-dimethyl-silanyloxy)-3-(dimethyl-phenyl-silanyl)-7-methyl-non-1-en-4-ol
  参考文献：
  名称：

  [(E)-γ-(Dimethylphenylsilyl)allyl]diisopinocampheylborane: a highly enantioselective reagent for the synthesis of anti-β-hydroxyallylsilanes

  摘要：

  anti-beta -Hydroxyallylsilanes are prepared with 88-95% e.e. via the asymmetric allylboration reactions of aldehydes and [(E)-gamma-(dimethylphenylsilyl)allyl]diisopinocampheylborane (7) (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01526-4

文献信息

• [(E)-γ-(Dimethylphenylsilyl)allyl]diisopinocampheylborane: a highly enantioselective reagent for the synthesis of anti-β-hydroxyallylsilanes
  作者：William R Roush、Anatoly N Pinchuk、Glenn C Micalizio

  DOI：10.1016/s0040-4039(00)01526-4

  日期：2000.12

  anti-beta -Hydroxyallylsilanes are prepared with 88-95% e.e. via the asymmetric allylboration reactions of aldehydes and [(E)-gamma-(dimethylphenylsilyl)allyl]diisopinocampheylborane (7) (C) 2000 Published by Elsevier Science Ltd.