2-((S)-2-Benzyloxy-1-{[2-((S)-5-benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-oxazole-4-carbonyl]-amino}-ethyl)-oxazole-4-carboxylic acid methyl ester | 301662-22-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((S)-2-Benzyloxy-1-{[2-((S)-5-benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-oxazole-4-carbonyl]-amino}-ethyl)-oxazole-4-carboxylic acid methyl ester
• 英文别名: methyl 2-[(1S)-1-[[2-[(1S)-1-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(phenylmethoxycarbonylamino)pentyl]-1,3-oxazole-4-carbonyl]amino]-2-phenylmethoxyethyl]-1,3-oxazole-4-carboxylate
• CAS: 301662-22-6
• 化学式: C₃₆H₄₃N₅O₁₀
• 分子量: 705.765
• InChiKey: SMEYBFXZBYNMAQ-XCZPVHLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  51
• 可旋转键数：
  21
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  193
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  2-((S)-2-Benzyloxy-1-{[2-((S)-5-benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-oxazole-4-carbonyl]-amino}-ethyl)-oxazole-4-carboxylic acid methyl ester 在 盐酸 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 碳酸氢钠 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.67h， 生成
  参考文献：
  名称：

  Functionalized platforms based on marine cyclopeptides: different pathways to the hexapeptide

  摘要：

  The synthesis of macrocyclic, roughly planar, exclusively syn-functionalized hexapeptides, related to dolastatin I and bistratamide C from enantiomerically pure oxazole precursors is reported. The platforms can either be synthesized in a stepwise procedure by final cyclization of the linear oxazole trimers or in a direct 'one-pot' reaction. The investigation on the coupling of these building blocks into linear dimers and trimers with modern peptide coupling reagents is reported. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01057-1
• 作为产物：
  描述：

  2-((S)-1-Amino-2-benzyloxy-ethyl)-oxazole-4-carboxylic acid methyl ester 、 2-((S)-5-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以61%的产率得到2-((S)-2-Benzyloxy-1-{[2-((S)-5-benzyloxycarbonylamino-1-tert-butoxycarbonylamino-pentyl)-oxazole-4-carbonyl]-amino}-ethyl)-oxazole-4-carboxylic acid methyl ester
  参考文献：
  名称：

  Functionalized platforms based on marine cyclopeptides: different pathways to the hexapeptide

  摘要：

  The synthesis of macrocyclic, roughly planar, exclusively syn-functionalized hexapeptides, related to dolastatin I and bistratamide C from enantiomerically pure oxazole precursors is reported. The platforms can either be synthesized in a stepwise procedure by final cyclization of the linear oxazole trimers or in a direct 'one-pot' reaction. The investigation on the coupling of these building blocks into linear dimers and trimers with modern peptide coupling reagents is reported. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)01057-1

文献信息

• Functionalized platforms based on marine cyclopeptides: different pathways to the hexapeptide
  作者：Christoph Boss、Palle H Rasmussen、Alexander R Wartini、Siegfried R Waldvogel

  DOI：10.1016/s0040-4039(00)01057-1

  日期：2000.8

  The synthesis of macrocyclic, roughly planar, exclusively syn-functionalized hexapeptides, related to dolastatin I and bistratamide C from enantiomerically pure oxazole precursors is reported. The platforms can either be synthesized in a stepwise procedure by final cyclization of the linear oxazole trimers or in a direct 'one-pot' reaction. The investigation on the coupling of these building blocks into linear dimers and trimers with modern peptide coupling reagents is reported. (C) 2000 Published by Elsevier Science Ltd.