8-(benzimidazol-2-ylthio)-N-[2,4-bis(ethylthio)-6-methyl-pyridin-3-yl]octanamide | 225941-25-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 8-(benzimidazol-2-ylthio)-N-[2,4-bis(ethylthio)-6-methyl-pyridin-3-yl]octanamide
• 英文别名: 8-(benzoimidazol-2-ylthio)-N-[2,4-bis(ethylthio)-6-methyl-3-pyridyl]octanamide；8-(benzimidazol-2-ylthio)-N-[2,4-bis(ethylthio)-6-methyl-3-pyridyl]octanamide；8-(1H-benzimidazol-2-ylsulfanyl)-N-[2,4-bis(ethylsulfanyl)-6-methylpyridin-3-yl]octanamide
• CAS: 225941-25-3
• 化学式: C₂₅H₃₄N₄OS₃
• 分子量: 502.769
• InChiKey: YDBJIIRSKAQYKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Novel amide compounds and medications containing the same
  申请人：Shibuya Kimiyuki

  公开号：US20050131002A1

  公开（公告）日：2005-06-16

  The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I) wherein represents an optionally substituted divalent residue such as benzene, pyridine, cyclohexane or naphthalene, or a group, Het represents a 5- to 8-membered, substituted or unsubstituted heterocyclic group containing at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, such as a monocyclic group, a polycyclic group or a group of a fused ring, X represents —NH—, an oxygen atom or a sulfur atom, Y represents —NR 4 —, an oxygen atom, a sulfur atom, a sulfoxide or a sulfone, Z represents a single bond or —NR 5 —, R 4 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, R 5 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, and n is an integer of from 1 to 15, or salts or solvates thereof, and a pharmaceutical composition containing at least one of these compounds.

  本发明提供了一种具有ACAT抑制活性的新化合物。本发明涉及由式(I)表示的化合物，其中表示一种可选取代的二价残基，例如苯，吡啶，环己烷或萘，或者一个基团，Het表示一种5-至8-成员的取代或未取代的杂环基团，其中至少包含从氮原子，氧原子和硫原子中选取的一种杂原子，例如单环基团，多环基团或融合环的基团，X表示-NH-，氧原子或硫原子，Y表示-NR4-，氧原子，硫原子，亚砜或磺酰基，Z表示单键或-NR5-，R4表示氢原子，低碳基，芳基或可选取代的硅烷低碳基，R5表示氢原子，低碳基，芳基或可选取代的硅烷低碳基，n为1到15的整数，或其盐或溶剂，以及含有这些化合物中至少一种的药物组合物。
• Novel amide compounds and medications containing the same technical field
  申请人：Shibuya Kimiyuki

  公开号：US20050131001A1

  公开（公告）日：2005-06-16

  The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I) wherein represents an optionally substituted divalent residue such as benzene, pyridine, cyclohexane or naphthalene, or a group, Het represents a 5- to 8-membered, substituted or unsubstituted heterocyclic group containing at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, such as a monocyclic group, a polycyclic group or a group of a fused ring, X represents —NH—, an oxygen atom or a sulfur atom, Y represents —NR 4 —, an oxygen atom, a sulfur atom, a sulfoxide or a sulfone, Z represents a single bond or —NR 5 —, R 4 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, R 5 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, and n is an integer of from 1 to 15, or salts or solvates thereof, and a pharmaceutical composition containing at least one of these compounds.

  本发明提供了一种具有ACAT抑制活性的新化合物。本发明涉及由式(I)表示的化合物，其中表示可选取代的二价残基，例如苯，吡啶，环己烷或萘，或基团，Het表示包含至少一种异原子（从氮原子，氧原子和硫原子中选择）的5-至8-成员取代或未取代的杂环基团，例如单环基团，多环基团或融合环基团，X表示-NH-，氧原子或硫原子，Y表示-NR4-，氧原子，硫原子，亚砜或磺酰基，Z表示单键或-NR5-，R4表示氢原子，低碳基，芳基或可选取代的硅基低碳基，R5表示氢原子，低碳基，芳基或可选取代的硅基低碳基，n为1至15的整数，或其盐或溶剂，以及含有这些化合物中至少一种的药物组合物。
• Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof
  申请人：——

  公开号：US20040122002A1

  公开（公告）日：2004-06-24

  The present invention relates to fused pyrrole compounds of the formula 1. 1 in which at least one of the radicals R1, R2, R3 is 4-sulphur-substituted phenyl. These compounds are in particular pyrrolizines, indolizines and heteroanalogues having selective inhibitory action on isoenzyme-2 of prostaglandin H synthase (COX-2). The invention also relates to pharmaceutical compositions which contain these compounds; and the use of these compounds for the treatment of disorders of the rheumatic type.

  本发明涉及式1.1的融合吡咯化合物，其中至少一个基团R1、R2、R3是4-硫代取代苯基。这些化合物特别是吡咯啉、吲哚啉和杂环类似物，具有对前列腺素H合成酶同工酶2的选择性抑制作用。本发明还涉及含有这些化合物的药物组合物；以及使用这些化合物治疗风湿性疾病的方法。
• Catalyst component for polymerization of olefins and process for production thereof
  申请人：MITSUBISHI PETROCHEMICAL CO., LTD.

  公开号：EP0166970A2

  公开（公告）日：1986-01-08

  A catalyst component for polymerization of olefins, which consists essentially of a particulate contact reaction product of an average particle size of 10 to 100 microns, obtained by contacting the surfaces of particles of a product of contact reaction with a magnesium halide and an alkoxy group-containing compound of a metal of Group I, II, III or IV of the Periodic Table with an alcohol compound and contacting the resulting contact reaction product with a liquid titanium halide. This catalyst component has a high activity and provides a polymer having a relatively large particle size and a narrow particle size distribution.

  一种用于烯烃聚合的催化剂组分，它主要由平均粒径为 10 至 100 微米的颗粒接触反应产物组成，这种接触反应产物是通过将接触反应产物的颗粒表面与卤化镁和元素周期表第 I、II、III 或 IV 族金属的含烷氧基化合物与醇化合物接触，并将所得接触反应产物与液态卤化钛接触而得到的。 这种催化剂组分具有很高的活性，并能提供一种粒径相对较大且粒径分布较窄的聚合物。
• Polymerization of olefins
  申请人：MITSUBISHI PETROCHEMICAL CO., LTD.

  公开号：EP0231878A2

  公开（公告）日：1987-08-12

  The present invention relates to a Ziegler catalyst which comprises a titanium-containing component and an organoaluminum component. The titanium-containing component is obtained by contacting a Ti, Mg and a halogen containing component with an alkoxyalkylsilane compound of which at least one of the alkyl groups has a branched structure. This catalyst does not require a so-called external electron donor, and no reduction of the polymerization velocity caused by the use of the electron donor is entailed. When this catalyst is used, a propylene/ethylene block copolymer can be prepared, in which the molecular weight of the propylene/ethylene copolymer portion and/or the polyethylene portion is increased, that is, the rigidity and impact strength are increased.

  本发明涉及一种齐格勒催化剂，它包括一种含钛组分和一种有机铝组分。含钛组分是通过将钛、镁和含卤素组分与烷氧基硅烷化合物接触而得到的，其中至少有一个烷基具有支链结构。这种催化剂不需要所谓的外部电子供体，也不会因使用电子供体而降低聚合速度。使用这种催化剂可以制备丙烯/乙烯嵌段共聚物，其中丙烯/乙烯共聚物部分和/或聚乙烯部分的分子量增加，即刚性和抗冲击强度增加。