isopropyl-(6-phenyl-5-{4-[3-(5-pyridin-2-yl-1H-[1,2,4]triazol-3-yl)-azetidin-1-ylmethyl]-phenyl}-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-amine | 1240468-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: isopropyl-(6-phenyl-5-{4-[3-(5-pyridin-2-yl-1H-[1,2,4]triazol-3-yl)-azetidin-1-ylmethyl]-phenyl}-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-amine
• 英文别名: 6-phenyl-N-propan-2-yl-5-[4-[[3-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)azetidin-1-yl]methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
• CAS: 1240468-15-8
• 化学式: C₃₁H₃₀N₁₀
• 分子量: 542.646
• InChiKey: HVGJZHHGYOCZDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• FUSED PYRIMIDINES
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2396330A1

  公开（公告）日：2011-12-21
• US8957064B2
  申请人：——

  公开号：US8957064B2

  公开（公告）日：2015-02-17
• [EN] FUSED PYRIMIDINES<br/>[FR] PYRIMIDINES CONDENSÉES
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2010091808A1

  公开（公告）日：2010-08-19

  Compounds of formula (I), or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.