(1'R,5α,6R,7R,14α)-1'-(2-methylphenyl)-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7β-methyl-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-methan-1'-ol | 1417783-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (1'R,5α,6R,7R,14α)-1'-(2-methylphenyl)-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7β-methyl-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-methan-1'-ol
• 英文别名: (1′R,5α,6R,7R,14α)-1′-(2-methylphenyl)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7β-methyl 17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)methan-1′-ol；BU12004；(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(R)-hydroxy-(2-methylphenyl)methyl]-15-methoxy-16-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
• CAS: 1417783-95-9
• 化学式: C₃₂H₃₉NO₄
• 分子量: 501.666
• InChiKey: ZNUQOEFQWALHAF-XOSCKEEYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  邻甲苯基溴化镁 在 六甲基磷酰三胺 、 lithium aluminium tetrahydride 、 草酰氯 、 四丁基溴化铵 、 二甲基亚砜 、 1-丙烷硫醇钠 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 76.33h， 生成 (1'R,5α,6R,7R,14α)-1'-(2-methylphenyl)-1'-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-7β-methyl-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-methan-1'-ol
  参考文献：
  名称：

  C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

  摘要：

  Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities relying on its partial agonist activity at mu opioid receptors. However, there is substantial interest in its activities at the kappa opioid and nociceptin/orphanin FQ peptide receptors. This has led to an interest in developing compounds with a buprenorphine-like pharmacological profile but with lower efficacy at mu opioid receptors. The present article describes aryl ring analogues of buprenorphine in which the standard C20-methyl group has been moved to the C7 beta position, resulting in ligands with the desired profile. In particular, moving the methyl group has resulted in far more robust kappa opioid antagonist activity than seen in the standard orvinol series. Of the compounds synthesized, a number, including 15a, have a profile of interest for the development of drug abuse relapse prevention therapies or antidepressants and others (e.g., 8c), as analgesics with a reduced side-effect profile.

  DOI：

  10.1021/acs.jmedchem.5b00130

文献信息

• ORVINOL AND THEVINOL DERIVATIVES USEFUL IN THE TREATMENT OF DRUG AND ALCOHOL ABUSE
  申请人：Lewis John

  公开号：US20140213603A1

  公开（公告）日：2014-07-31

  The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.

  这项发明提供了用于治疗药物和酒精滥用的奥维诺尔（orvinol）和西维诺尔（thevinol）化合物，这些化合物特别适用于预防康复成瘾者的复发。
• Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse, depression, anxiety, or a compulsive disorder
  申请人：The University of Bath

  公开号：US10030031B2

  公开（公告）日：2018-07-24

  The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.

  本发明提供了一种治疗吸毒和酗酒、抑郁、焦虑或强迫症的方法，该方法包括向受试者施用一种具有以下式子的化合物： 或其药学上可接受的盐或溶液，其中 R、R1、R2、R3、R4、R5 和 X 如说明书中所定义。
• Orvinol and Thevinol Derivatives Useful in the Treatment of Drug and Alcohol Abuse
  申请人：The University of Bath

  公开号：US20150202200A1

  公开（公告）日：2015-07-23

  The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.
• Orvinol and Thevinol Derivatives Useful in the Treatment of Anxiety or a Compulsive Disorder
  申请人：The University of Bath

  公开号：US20160136151A1

  公开（公告）日：2016-05-19

  The invention provides a method of treating anxiety or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and X are as defined in the specification.
• Orvinol and Thevinol Derivatives Useful in the Treatment of Drug and Alcohol Abuse, Depression, Anxiety, or a Compulsive Disorder
  申请人：The University of Bath

  公开号：US20170044173A1

  公开（公告）日：2017-02-16

  The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2 : or a pharmaceutically acceptable salt or solvate thereof, wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and X are as defined in the specification.