7-acetoxy-6-bromo-4-formylcoumarin p-tosylhydrazone | 272107-63-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-acetoxy-6-bromo-4-formylcoumarin p-tosylhydrazone
• 英文别名: [6-bromo-4-[[(4-methylphenyl)sulfonylhydrazinylidene]methyl]-2-oxochromen-7-yl] acetate
• CAS: 272107-63-8
• 化学式: C₁₉H₁₅BrN₂O₆S
• 分子量: 479.308
• InChiKey: YLTPUNLURDHUIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  7-acetoxy-6-bromo-4-formylcoumarin p-tosylhydrazone 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 48.0h， 以79%的产率得到6-bromo-4-diazomethyl-7-hydroxycoumarin
  参考文献：
  名称：

  Photoregulation of thrombin aptamer activity using Bhc caging strategy

  摘要：

  Thrombin aptamer was attempted to cage with Bhc (6-bromo-7-hydroxycoumarin-4-ylmethyl) group for controlling its specific affinity to target molecular through photolysis. By multiple-caging strategy, aptamer could be rendered biologically inert and partially restored with subsequently illumination. This provides a convenient method for photoregulating aptamer activity with exact spatiotemporal resolution. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.128
• 作为产物：
  描述：

  7-acetoxy-6-bromo-4-formylcoumarin 、 对甲苯磺酰肼 以 乙醇 为溶剂， 反应 19.0h， 以82%的产率得到7-acetoxy-6-bromo-4-formylcoumarin p-tosylhydrazone
  参考文献：
  名称：

  Photoregulation of thrombin aptamer activity using Bhc caging strategy

  摘要：

  Thrombin aptamer was attempted to cage with Bhc (6-bromo-7-hydroxycoumarin-4-ylmethyl) group for controlling its specific affinity to target molecular through photolysis. By multiple-caging strategy, aptamer could be rendered biologically inert and partially restored with subsequently illumination. This provides a convenient method for photoregulating aptamer activity with exact spatiotemporal resolution. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.128