2-[2-(2,6-dichloroanilino)phenyl]-N-[2-(2-hydroxyethoxy)ethyl]acetamide | 683748-94-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(2,6-dichloroanilino)phenyl]-N-[2-(2-hydroxyethoxy)ethyl]acetamide
• CAS: 683748-94-9
• 化学式: C₁₈H₂₀Cl₂N₂O₃
• 分子量: 383.274
• InChiKey: PRWBZDKKXFLKAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  70.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  acetic acid N-oxysuccinimide ester 、 二甘醇胺 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以78%的产率得到2-[2-(2,6-dichloroanilino)phenyl]-N-[2-(2-hydroxyethoxy)ethyl]acetamide
  参考文献：
  名称：

  [EN] N-PHENYL ANTHRANILIC ACID DERIVATIVES AND USES THEREOF
  [FR] DÉRIVÉS DE L'ACIDE N-PHÉNYLANTHRANILIQUE ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2009037707A3

文献信息

• N-PHENYL ANTHRANILIC ACID DERIVATIVES AND USES THEREOF
  申请人：Attali Bernard

  公开号：US20100137296A1

  公开（公告）日：2010-06-03

  Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing or enhancing cortical and/or peripheral neuron activity, compositions containing same and methods utilizing same are disclosed. Also disclosed are modulators of voltage-dependent potassium channels, which exhibit blocking of a TRPV1 channel, and hence are useful in the treatment of TRPV1-related conditions.

  本发明揭示了可以用作电压依赖性钾离子通道的开放剂或阻断剂的化合物，其通过调节电压依赖性钾离子通道中的钾离子通量和/或抑制或增强皮质和/或外周神经元活动，在治疗中枢或外周神经系统疾病方面具有用途，以及包含该化合物的组合物和利用该化合物的方法。此外，本发明还揭示了电压依赖性钾离子通道的调节剂，其表现出对TRPV1通道的阻断作用，因此在治疗TRPV1相关疾病方面具有用途。
• Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
  申请人：Attali Bernard

  公开号：US20100056591A1

  公开（公告）日：2010-03-04

  Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortical and/or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.
• DERIVATIVES OF N-PHENYLANTHRANILIC ACID AND 2-BENZIMIDAZOLONE AS POTASSIUM CHANNEL AND/OR NEURON ACTIVITY MODULATORS
  申请人：ATTALI Bernard

  公开号：US20120178785A1

  公开（公告）日：2012-07-12

  Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortical and/or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.
• US7632866B2
  申请人：——

  公开号：US7632866B2

  公开（公告）日：2009-12-15
• US8278357B2
  申请人：——

  公开号：US8278357B2

  公开（公告）日：2012-10-02