2,6-difluorophenyl isocyanide | 115591-42-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-difluorophenyl isocyanide
• 英文别名: 2,6-difluorophenyl isocyanate；1,3-Difluoro-2-isocyanobenzene
• CAS: 115591-42-9
• 化学式: C₇H₃F₂N
• mdl: MFCD08059032
• 分子量: 139.104
• InChiKey: VSRDGLVOQRBOMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  4.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-amino-pyrazole-3-carboxylic acid methyl-amide 、 2,6-difluorophenyl isocyanide 以 甲苯 为溶剂， 反应 1.0h， 生成 4-[(2,6-difluorophenyl)carbamoylamino]-N-methyl-1H-pyrazole-5-carboxamide
  参考文献：
  名称：

  WO2006/77414

  摘要：

  公开号：
• 作为产物：
  描述：

  N-(2,6-difluorophenyl)formamide 在 N-甲基吗啉 、 氯甲酸三氯甲酯 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以15%的产率得到2,6-difluorophenyl isocyanide
  参考文献：
  名称：

  旋光镍(II)配合物催化非手性异氰化物的螺杆选择性聚合

  摘要：

  各种非手性异氰化物与该催化剂的聚合产生光学活性聚合物，其对映体过量高达 83%。在质子酸、路易斯酸或 Ni(II) 盐作为催化剂存在下，异氰化物聚合生成聚（异氰化物），也称为聚（亚氨基亚甲基）或聚（碳酰亚胺酰基）。1,2 Ni(II) 盐是多功能催化剂，在我们看来，最适合我们的实验。聚（异氰化物）是方案 I n Ni(II) ( RN = C < ) 中的不寻常聚合物 „ 其主链的每个原子都带有侧链 .1,2 这一特征导致围绕单键的旋转受限连接主链碳原子。单键周围可能有两种构象，即。R 和 S 。所得聚合物将是具有P和M螺杆的非对映异构分子的混合物。这种混合物将包含过量的一种螺旋感。在大约 20 种不同的光学活性异氰化物 0.10" 12 中观察到了这一点。在另一个过程中，我们通过特异性抑制外消旋对的一个螺旋方向的生长来制备光学活性聚合物。5,13 最后，在一种情况下，光学活性聚合物活性聚

  DOI：

  10.1021/ja00228a035

文献信息

• Isolation of 1,2,4,3-Triazaborol-3-yl-metal (Li, Mg, Al, Au, Zn, Sb, Bi) Derivatives and Reactivity toward CO and Isonitriles
  作者：Wei Lu、Haitao Hu、Yongxin Li、Rakesh Ganguly、Rei Kinjo

  DOI：10.1021/jacs.6b03432

  日期：2016.5.25

  1,2,4,3-triazaborol-3-yl-metal complexes (Al; 5, Au; 6, Zn; 7, Mg; 8, Sb; 9, and Bi; 10). 3 reacted with CO (1 atm) and various isonitriles under ambient condition, and mechanistic study suggests that the reactions with CO and aryl isonitriles proceed via an insertion of CO and isonitrile carbon into the B-Li bond followed by isomerization to yield transient carbene species, one of which was confirmed

  合成并充分表征了 3,4-二氢-2H-1,2,4,3-triazaborol-3-yl-lithium 3。(11)B NMR 光谱、X 射线衍射分析和计算研究揭示了 B-Li 键的离子性质，实际上 3 显示出亲核性质，允许制备一系列 1,2,4,3-triazaborol -3-基-金属络合物（Al；5，Au；6，Zn；7，Mg；8，Sb；9 和 Bi；10）。3 在环境条件下与 CO (1 atm) 和各种异腈反应，机理研究表明，与 CO 和芳基异腈的反应是通过将 CO 和异腈碳插入 B-Li 键然后异构化产生瞬态卡宾物种来进行的，其中之一通过 S8 诱捕确认。使用PhNC，化合物5和7·(thf)与异腈交换了与金属中心配位的THF分子，
• Synthesis of N-Heterocyclic Carbene Complexes of Manganese(I) by Coupling Isocyanide Ligands with Propargylamines and Propargylic Alcohols
  作者：Javier Ruiz、Bernabé F. Perandones、Gabriel García、Marta E. G. Mosquera

  DOI：10.1021/om700718x

  日期：2007.11.1

  A variety of N-heterocyclic carbene (NHC) complexes of general formula fac-[Mn(NHC)(CO)3(bipy)]+ have been prepared by reaction of the manganese(I) isocyanide complexes fac-[Mn(CNR)(CO)3(bipy)]+ with propargylamines and propargylic alcohols and characterized by spectroscopic and X-ray diffraction methods.

  通过异氰酸锰（I）配合物fac- [Mn（CNR）的反应，制备了各种通式为fac- [Mn（NHC）（CO）3（bipy）] +的N-杂环卡宾（NHC）配合物（CO）3（bipy）] +与炔丙基胺和炔丙基醇的混合物，并通过光谱和X射线衍射方法进行了表征。
• Novel Sulfonic-Acid-Group-Containing Segmented Block Copolymer, Application Thereof, and Method of Manufacturing Novel Block Copolymer
  申请人：Kitamura Kouta

  公开号：US20110065021A1

  公开（公告）日：2011-03-17

  [Object] To provide a proton exchange membrane for a fuel cell having excellent proton conductivity, lower property of swelling with hot water, and excellent durability, as well as a block copolymer forming the proton exchange membrane, and a composition, a molded product, a fuel cell proton exchange membrane electrode assembly, and a fuel cell. [Solving Means] (1) A block copolymer having a hydrophilic segment and a hydrophobic segment and having a structure expressed by Chemical Formula 1 below (where X represents H or a univalent cation, Y represents sulfonyl group or carbonyl group, each of Z and z′ independently represents any of O and S atoms, W represents one or more group selected from the group consisting of direct bond between benzenes, sulfone group and carbonyl group, each of Ar 1 and Ar 2 independently represents divalent aromatic group, and each of n and m independently represents an integer from 2 to 100), and a molded product, a composition, and a proton exchange membrane, as well as a fuel cell including the proton exchange membrane.
• PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS
  申请人：Tachdjian Catherine

  公开号：US20110245494A1

  公开（公告）日：2011-10-06

  The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
• Novel Sulfonic Acid Group-Containing Segmented Block Copolymer and Use Thereof
  申请人：Ichimura Shunsuke

  公开号：US20120129076A1

  公开（公告）日：2012-05-24

  Disclosed is a proton exchange membrane for use in fuel cells, which not only has improved proton conductivity and resistance to swelling caused by hot water but also has greater durability when used in a fuel cell, as well as a sulfonic acid group-containing segmented block copolymer constituting the proton exchange membrane, a membrane electrode assembly using the proton exchange membrane, and a fuel cell using the membrane electrode assembly. A sulfonic acid group-containing segmented block copolymer, which is a di- or multi-block copolymer including, within a molecule, at least one kind of hydrophilic segment and at least one kind of hydrophobic segment, a 0.5 g/dL solution thereof dissolved in N-methyl-2-pyrrolidone as a solvent showing a logarithmic viscosity measured at 30° C. in the range of 0.5 to 5.0 dL/g, wherein the copolymer has at least one kind of hydrophobic segment represented by Chemical Formula 1, the segment has a structure bound to a group represented by Chemical Formula 2, and the hydrophilic segment has at least one kind of structure represented by Chemical Formula 3 or Chemical Formula 3-2.