3-phenyl-1,3-di(o-tolyl)propan-1-ol | 1029874-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenyl-1,3-di(o-tolyl)propan-1-ol
• 英文别名: 1,3-Bis(2-methylphenyl)-3-phenylpropan-1-ol
• CAS: 1029874-79-0
• 化学式: C₂₃H₂₄O
• 分子量: 316.443
• InChiKey: AAEJUMXPSHIGDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基苯硼酸 、 肉桂醛 在 potassium phosphate 、 platinacycle 作用下， 以 甲苯 为溶剂， 以66%的产率得到3-phenyl-1,3-di(o-tolyl)propan-1-ol
  参考文献：
  名称：

  Orthoplatinated Triarylphosphite as a Highly Efficient Catalyst for Addition Reactions of Arylboronic Acids with Aldehydes: Low Catalyst Loading Catalysis and a New Tandem Reaction Sequence

  摘要：

  Readily available, air/moisture-stable orthoplatinated triarylphosphite catalyzes the addition reactions of arylboronic acids with aldehydes with the catalyst loading as low as 0.01%. It also cataylzes a new tandem reaction of arylboronic acids with alpha,beta-unsaturated aldehydes to form 1,3-diaryl-1-propanols. Our study provides a new paradigm for the application of orthoplatinated triarylphosphites, and may pave the road to develop other Pt(II) catalysts for such addition reactions and other tandem reactions with such addition reactions as part of the reaction sequence.

  DOI：

  10.1021/ol800774c

文献信息

• Rh(I)/diene-catalyzed addition reactions of aryl/alkenylboronic acids with aldehydes
  作者：Chun-Hui Xing、Tao-Ping Liu、Jin Rong Zheng、Jaclynn Ng、Michelle Esposito、Qiao-Sheng Hu

  DOI：10.1016/j.tetlet.2009.06.074

  日期：2009.9

  [Rh(COD)Cl]2-catalyzed addition reactions of arylboronic acids with aldehydes, with low Rh(I) catalyst loading, are described. We also found that the reaction of arylboronic acids with α,β-unsaturated aldehydes greatly depends on the solvent and the steric hindrance of the reagents/substrates.

  描述了在低Rh（I）催化剂负载下[Rh（COD）Cl] 2催化的芳基硼酸与醛的加成反应。我们还发现，芳基硼酸与α，β-不饱和醛的反应在很大程度上取决于溶剂和试剂/底物的空间位阻。