4-(4-甲基吡啶-2-基)苯甲醛 | 289469-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-(4-甲基吡啶-2-基)苯甲醛
• 中文别名: 2-[4-(吗啉-4-羰基)喹啉-2-基]丙二腈
• 英文名称: 4-(4-methylpyridin-2-yl)benzaldehyde
• CAS: 289469-97-2
• 化学式: C₁₃H₁₁NO
• 分子量: 197.236
• InChiKey: GHBLNQSCMJBLNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-甲基吡啶-2-基)苯甲醛 在 盐酸羟胺 作用下， 以 乙醇 为溶剂， 生成 4-(4-methylpyridin-2-yl)benzaldehyde oxime
  参考文献：
  名称：

  Pyridine compounds and their pharmaceutical use

  摘要：

  根据所附的规格说明书，本发明的化合物(I)和药用可接受的盐具有强烈的抑制一氧化氮(NO)生成的活性，并且可用于预防或治疗由NOS（一氧化氮合酶）介导的疾病，例如成人的呼吸窘迫综合征、心肌炎、滑膜炎、败血症休克、胰岛素依赖型糖尿病、溃疡性结肠炎、脑梗塞、类风湿性关节炎、骨关节炎、骨质疏松症、系统性红斑狼疮、器官移植排斥反应、哮喘、疼痛、溃疡等人类和动物的疾病。

  公开号：

  US06521643B1
• 作为产物：
  描述：

  2-氯-4-甲基吡啶 、 4-羟甲基苯硼酸 在 C₄₆H₄₉BrClFeN₃Pd 、 copper diacetate 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以82%的产率得到4-(4-甲基吡啶-2-基)苯甲醛
  参考文献：
  名称：

  Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N -heterocyclic carbenes (NHCs) and triphenylphosphine

  摘要：

  Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh3 1-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboronic acid containing hydroxymethyl was also investigated. An efficient 3/Cu cocatalyzed oxidation/Suzuki coupling of aryl chlorides with phenylboronic acids containing hydroxymethyl in air has been developed. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.07.037

文献信息

• PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1157022A1

  公开（公告）日：2001-11-28
• US6521643B1
  申请人：——

  公开号：US6521643B1

  公开（公告）日：2003-02-18
• [EN] PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE<br/>[FR] COMPOSES PYRIDINE ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2000049015A1

  公开（公告）日：2000-08-24

  A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NOS(nitric oxide synthase)-mediated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, insulin-dependent diabetes mellitus, ulcerative colitis, cerebral infarction, rheumatoid arthritis, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, pain, ulcer, and the like in human being and animals.
• Pyridine compounds and their pharmaceutical use
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US06521643B1

  公开（公告）日：2003-02-18

  A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NOS(nitric oxide synthasey)-mediated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, insulin-ependent diabetes mellitus, ulcerative colitis, cerebral infarction, rheumatoid arthritis, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, pain, ulcer, and the like in human being and animals.

  根据所附的规格说明书，本发明的化合物(I)和药用可接受的盐具有强烈的抑制一氧化氮(NO)生成的活性，并且可用于预防或治疗由NOS（一氧化氮合酶）介导的疾病，例如成人的呼吸窘迫综合征、心肌炎、滑膜炎、败血症休克、胰岛素依赖型糖尿病、溃疡性结肠炎、脑梗塞、类风湿性关节炎、骨关节炎、骨质疏松症、系统性红斑狼疮、器官移植排斥反应、哮喘、疼痛、溃疡等人类和动物的疾病。
• Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N -heterocyclic carbenes (NHCs) and triphenylphosphine
  作者：Chen Xu、Hong-Mei Li、Zhi-Qiang Wang、Wei-Jun Fu

  DOI：10.1016/j.ica.2014.07.037

  日期：2014.11

  Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh3 1-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboronic acid containing hydroxymethyl was also investigated. An efficient 3/Cu cocatalyzed oxidation/Suzuki coupling of aryl chlorides with phenylboronic acids containing hydroxymethyl in air has been developed. (C) 2014 Elsevier B.V. All rights reserved.