N4-(5-methyl-1H-pyrazol-3-yl)-N6-(tetrahydro-2H-pyran-4-yl)-2-(2-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine | 1093109-21-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N4-(5-methyl-1H-pyrazol-3-yl)-N6-(tetrahydro-2H-pyran-4-yl)-2-(2-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine
• 英文别名: 6-N-(5-methyl-1H-pyrazol-3-yl)-4-N-(oxan-4-yl)-2-[2-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine
• CAS: 1093109-21-7
• 化学式: C₂₀H₂₁F₃N₆O
• 分子量: 418.422
• InChiKey: NCMVJCHSGKOCBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  87.8
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• SUBSTITUTED PYRAZOLE COMPOUNDS
  申请人：AGOSTON GREGORY E.

  公开号：US20090029992A1

  公开（公告）日：2009-01-29

  Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.

  本发明涉及蛋白激酶抑制剂、包含这些抑制剂的组合物以及使用它们的方法。更具体地，本发明涉及Aurora A（Aurora-2）蛋白激酶的抑制剂。本发明还涉及治疗与蛋白激酶相关的疾病的方法，特别是与Aurora-2相关的疾病，如癌症。
• [EN] SUBSTITUTED PYRAZOLE COMPOUNDS<br/>[FR] COMPOSÉS PYRAZOLE SUBSTITUÉS
  申请人：MIIKANA THERAPEUTICS INC

  公开号：WO2008154026A1

  公开（公告）日：2008-12-18

  [EN] Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.
  [FR] L'invention concerne des inhibiteurs de protéines kinases, les compositions comprenant de tels inhibiteurs, et leurs procédés d'utilisation. Plus particulièrement, l'invention concerne les inhibiteurs de la protéine kinase Aurora A (Aurora-2). L'invention concerne également des procédés de traitement des maladies associées aux protéines kinases, en particulier aux maladies associées à Aurora-2, telles que le cancer.