6'-(methyl-N-Boc-1-aminomethyl-cyclopropyl)-2',3,3''-triBoc-1-(2-(N-Boc-azetidin-3-yl)-2-hydroxy-acetyl)-sisomicin | 1154760-13-0

• 分子结构分类: 有机化合物
• 英文名称: 6'-(methyl-N-Boc-1-aminomethyl-cyclopropyl)-2',3,3''-triBoc-1-(2-(N-Boc-azetidin-3-yl)-2-hydroxy-acetyl)-sisomicin
• 英文别名: tert-butyl 3-[2-[[(1R,2S,3S,4R,5S)-2-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]oxan-2-yl]oxy-3-hydroxy-5-[(2-methylpropan-2-yl)oxycarbonylamino]-4-[[(2S,3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]-6-[[[1-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]cyclopropyl]methylamino]methyl]-3,4-dihydro-2H-pyran-2-yl]oxy]cyclohexyl]amino]-1-hydroxy-2-oxoethyl]azetidine-1-carboxylate
• CAS: 1154760-13-0
• 化学式: C₅₄H₉₃N₇O₁₉
• 分子量: 1144.37
• InChiKey: YUIGSYLJHFHPLA-HDQDJCOHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  80
• 可旋转键数：
  26
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  333
• 氢给体数：
  9
• 氢受体数：
  20

文献信息

• ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
  申请人：Aggen James Bradley

  公开号：US20100099661A1

  公开（公告）日：2010-04-22

  Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 8 and R 9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本发明揭示了具有抗菌活性的化合物。这些化合物具有以下结构（I）：包括立体异构体，药学上可接受的盐和其前药，其中Q1、Q2、Q3、R8和R9的定义如本文所述。本发明还揭示了与制备和使用这种化合物相关的方法，以及包含这种化合物的药物组合物。
• TREATMENT OF KLEBSIELLA PNEUMONIAE INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS
  申请人：Bruss Jon B.

  公开号：US20120214759A1

  公开（公告）日：2012-08-23

  A method for treating a Klebsiella pneumonia infection in a mammal in need thereof is disclosed, the method comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound.

  本发明揭示了一种用于治疗哺乳动物中的肺炎克雷伯菌感染的方法，该方法包括向哺乳动物投与一种有效量的抗菌氨基糖苷化合物。
• TREATMENT OF URINARY TRACT INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS
  申请人：Bruss Jon B.

  公开号：US20120214760A1

  公开（公告）日：2012-08-23

  A method for treating a urinary tract infection in a mammal in need thereof is disclosed, the method comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound.

  本发明揭示了一种用于治疗哺乳动物尿路感染的方法，该方法包括向哺乳动物施用有效量的抗菌氨基糖苷化合物。
• Antibacterial aminoglycoside analogs
  申请人：Cipla USA, Inc.

  公开号：US11117915B2

  公开（公告）日：2021-09-14

  Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本发明公开了具有抗菌活性的化合物。这些化合物具有以下结构 (I)： 包括其立体异构体、药学上可接受的盐和原药，其中 Q1、Q2、Q3、R8 和 R9 如本文所定义。此外，还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• US8383596B2
  申请人：——

  公开号：US8383596B2

  公开（公告）日：2013-02-26