N-[(6S)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]-3-[(2R)-1-(4-methyl-2-pyridin-4-yl-1,3-thiazole-5-carbonyl)pyrrolidin-2-yl]benzamide | 1354719-16-6

• 分子结构分类: 有机化合物
• 英文名称: N-[(6S)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]-3-[(2R)-1-(4-methyl-2-pyridin-4-yl-1,3-thiazole-5-carbonyl)pyrrolidin-2-yl]benzamide
• CAS: 1354719-16-6
• 化学式: C₃₀H₃₂N₆O₂S₂
• 分子量: 572.755
• InChiKey: LTNIAWNRRZEOCA-LADGPHEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  148
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] RHO KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA RHO KINASE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2012006202A1

  公开（公告）日：2012-01-12

  The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase-mediated disorders selected from hypertension, atherosclerosis, restenosis, stroke, myocardial infarction, heart failure, coronary artery disease, peripheral artery disease, coronary vasospasm, cerebral vasospasm, ischemia/reperfusion injury, pulmonary hypertension, angina, erectile dysfunction, renal disease, organ failure, asthma, glaucoma, cancer, Alzheimer's disease, multiple sclerosis, spinal cord injury, neuropathic pain, rheumatoid arthritis, psoriasis inflammatory bowel disease, and combinations of such disorders.

  本发明涉及化合物的结构式（I）及其药学上可接受的盐，其中R1和X如本文所定义。本发明还涉及包含这些化合物的制药组合物，以及使用这些化合物治疗从高血压、动脉粥样硬化、再狭窄、中风、心肌梗死、心力衰竭、冠状动脉疾病、外周动脉疾病、冠状动脉痉挛、脑血管痉挛、缺血/再灌注损伤、肺动脉高压、心绞痛、勃起功能障碍、肾脏疾病、器官衰竭、哮喘、青光眼、癌症、阿尔茨海默病、多发性硬化症、脊髓损伤、神经性疼痛、类风湿性关节炎、银屑病、炎症性肠病等Rho激酶介导的疾病的方法，以及这些疾病的组合。
• RHO KINASE INHIBITORS
  申请人：GINN John David

  公开号：US20120178752A1

  公开（公告）日：2012-07-12

  The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R 1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  本发明涉及式(I)的化合物及其药学上可接受的盐，其中R1和X的定义如本文所述。本发明还涉及包含这些化合物的制药组合物，使用这些化合物治疗各种疾病和疾病的方法，制备这些化合物的过程以及在这些过程中有用的中间体。
• US9079880B2
  申请人：——

  公开号：US9079880B2

  公开（公告）日：2015-07-14