succinic acid ethyl ester-phenyl ester | 860426-16-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: succinic acid ethyl ester-phenyl ester
• 英文别名: Bernsteinsaeure-aethylester-phenylester；1-O-ethyl 4-O-phenyl butanedioate
• CAS: 860426-16-0
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: IXQVKBNABYSWHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  succinic acid ethyl ester-phenyl ester 在 三氯化铝 作用下， 生成 4-(4-羟基苯基)-4-氧代丁酸
  参考文献：
  名称：

  Treibs; Falk, Chemische Berichte, 1954, vol. 87, p. 345,348

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氧代-4-苯氧基丁酸 在 氯化亚砜 作用下， 生成 succinic acid ethyl ester-phenyl ester
  参考文献：
  名称：

  Treibs; Falk, Chemische Berichte, 1954, vol. 87, p. 345,348

  摘要：

  DOI：

文献信息

• Breast cancer resistance protein (bcrp) inhibitor
  申请人：Yamazaki Ryuta

  公开号：US20060128636A1

  公开（公告）日：2006-06-15

  The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [wherein, each of 8 R's, which are the same or different from one another, represents a hydrogen atom, a hydroxyl group, a nitro group, an amino group, an acetylamino group (—NHCOCH 3 group); a cyano group (—CN group); a formyl group (—CHO group), —COOR 1 (R 1 is hydrogen or C1-C4 alkyl), —O(CH 2 ) n COOR 2 (n=1−7: R 2 is hydrogen or C1-C4 alkyl), —OOCCH 2 CH 2 COOR 3 (R 3 is hydrogen, C1-C4 alkyl, (Z)-2-(3,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile, or glycopyranosyl), a C1-C8 alkoxy group, a C1-C4 alkyl group, a halogen atom, a C1-C4 alkoxy C1-C4 alkoxy C1-C4 alkoxy group, a C2-C8 acyloxy group, a C2-C8 halogenoacyloxy group, a methylenedioxy group, a trifluoromethyl group, a phosphate group (i.e., —OP(O) (OH) 2 ) or a salt thereof, a sulfate group (i.e., —OSO 3 H) or a salt thereof, a glycopyranosyl group or a salt thereof, a phosphate ester of a glycopyranosyl group or a salt of the ester, a sulfate ester of a glycopyranosyl group or a salt of the ester, or a piperidinopiperidinocarbonyloxy group], an ester thereof, or a salt thereof.

  本发明提供了一种抑制BCRP的药物。一种含有以下式（1）所表示的二苯乙烯腈衍生物作为活性成分的乳腺癌耐药蛋白抑制剂：[其中，8个R分别表示氢原子、羟基、硝基、氨基、乙酰氨基（—NHCOCH3基）、氰基（—CN基）、甲酰基（—CHO基）、—COOR1（R1为氢或C1-C4烷基）、—O（CH2）nCOOR2（n = 1-7：R2为氢或C1-C4烷基）、—OOCCH2CH2COOR3（R3为氢、C1-C4烷基、（Z）-2-（3,4-二甲氧基苯基）-3-（4-羟基苯基）-丙烯腈或葡萄糖基）、C1-C8烷氧基、C1-C4烷基、卤原子、C1-C4烷氧基C1-C4烷氧基C1-C4烷氧基、C2-C8酰氧基、C2-C8卤代酰氧基、亚甲二氧基基团、三氟甲基基团、磷酸酯基团（即—OP（O）（OH）2）或其盐、硫酸酯基团（即—OSO3H）或其盐、葡萄糖基或其盐、葡萄糖基的磷酸酯或酯的盐、葡萄糖基的硫酸酯或酯的盐，或者是它的酯或盐。
• METHOD FOR PRODUCING ORGANIC COMPOUND AND ORGANIC COMPOUND OBTAINED BY THE METHOD
  申请人：Enomura Masakazu

  公开号：US20110178199A1

  公开（公告）日：2011-07-21

  Disclosed herein are a reaction method and a production method of an organic compound which are capable of achieving high reaction selectivity according to the purpose and a high production rate of a target substance. The methods include at least two fluids, wherein at least one kind of the fluids is a fluid containing at least one organic compound and at least one kind of the fluids other than the above fluid is a fluid containing at least one reactant in the form of a liquid or solution, and the respective fluids join together in a thin film fluid foamed between processing surfaces arranged to be opposite to each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, whereby an organic reaction is performed in the thin film fluid.

  本文公开了一种有机化合物的反应方法和生产方法，能够根据目的实现高反应选择性和目标物质的高产率。该方法包括至少两种流体，其中至少一种流体是含有至少一种有机化合物的流体，除上述流体外的至少一种流体是以液态或溶液形式含有至少一种反应物的流体。这些各自的流体在处理表面之间形成一个薄膜流体泡沫，这些处理表面相对排列以便能够相互接近和分离，其中至少有一个表面相对于另一个表面旋转，从而在薄膜流体中进行有机反应。
• METHOD FOR PRODUCING NANOPARTICLES BY FORCED ULTRA-THIN FILM ROTARY PROCESSING
  申请人：M Technique Co., Ltd.

  公开号：EP2184109A1

  公开（公告）日：2010-05-12

  The present invention provides a method for producing nanoparticles, which comprises maintaining a minute space of 1 mm or less between two processing surfaces capable of approaching to and separating from each other and being rotating relative to each other, allowing the minute space maintained between the two processing surfaces to serve as a flow path of a processed fluid thereby forming a forced thin film of the processed fluid and separating nanoparticles in the forced thin film.

  本发明提供了一种生产纳米颗粒的方法，该方法包括在两个能够相互接近和分离并相对旋转的加工表面之间保持 1 毫米或更小的微小空间，使两个加工表面之间保持的微小空间成为加工流体的流动路径，从而形成加工流体的强制薄膜，并分离强制薄膜中的纳米颗粒。
• PROCESS FOR PRODUCING ORGANIC COMPOUND AND ORGANIC COMPOUND OBTAINED BY THE SAME
  申请人：M Technique Co., Ltd.

  公开号：EP2216312A1

  公开（公告）日：2010-08-11

  Disclosed herein are a reaction method and a production method of an organic compound which are capable of achieving high reaction selectivity according to the purpose and a high production rate of a target substance. The methods include at least two fluids, wherein at least one kind of the fluids is a fluid containing at least one organic compound and at least one kind of the fluids other than the above fluid is a fluid containing at least one reactant in the form of a liquid or solution, and the respective fluids join together in a thin film fluid formed between processing surfaces arranged to be opposite to each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, whereby an organic reaction is performed in the thin film fluid.

  本文公开了一种有机化合物的反应方法和生产方法，该方法能够根据目的实现高反应选择性和目标物质的高生产率。这些方法包括至少两种流体，其中至少一种流体是含有至少一种有机化合物的流体，而除上述流体之外的至少一种流体是含有至少一种液体或溶液形式的反应物的流体，各自的流体以薄膜流体的形式结合在一起，薄膜流体形成于彼此相对的加工表面之间，以便能够相互接近和分离，其中至少一个加工表面相对于另一个加工表面旋转，从而在薄膜流体中进行有机反应。
• Preparation of diketopyrrolopyrrole pigments
  申请人：Clariant GmbH

  公开号：US20020010331A1

  公开（公告）日：2002-01-24

  A process for preparing diketopyrrolopyrrole pigments comprises conducting the elementary steps of pigment synthesis (reaction and hydrolysis) in a miniaturized continuous reactor.

  制备二酮吡咯啉颜料的工艺包括在小型连续反应器中进行颜料合成的基本步骤（反应和水解）。