2,3-Dichloro-5-(piperidine-1-carbonyl)pyridine | 577967-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,3-Dichloro-5-(piperidine-1-carbonyl)pyridine
• 英文别名: (5,6-dichloropyridin-3-yl)-piperidin-1-ylmethanone
• CAS: 577967-83-0
• 化学式: C₁₁H₁₂Cl₂N₂O
• mdl: MFCD09806137
• 分子量: 259.135
• InChiKey: AXSJDGHQFMXGFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-环丙基哌嗪 、 2,3-Dichloro-5-(piperidine-1-carbonyl)pyridine 生成 [5-chloro-6-(4-cyclopropyl-piperazin-1-yl)-pyridin-3-yl]-piperidin-1-ylmethanone hydrochloride
  参考文献：
  名称：

  Novel aryl- and heteroarylpiperazines

  摘要：

  小说芳基和杂环芳基哌嗪，这些化合物的药物组成物的使用，包含这些化合物的药物组成物，以及使用这些化合物和组成物的治疗方法。这些化合物显示出高度和选择性的结合亲和力，表明组胺H3受体拮抗，反向激动剂或激动剂活性。因此，这些化合物对于治疗与组胺H3受体相关的疾病和障碍非常有用。

  公开号：

  US20030236259A1
• 作为产物：
  描述：

  哌啶 、 2,3-二氯吡啶-5-羰酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 2,3-Dichloro-5-(piperidine-1-carbonyl)pyridine
  参考文献：
  名称：

  Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity

  摘要：

  High throughput screening led to the identification of nicotinamide derivative 2 as a structurally novel mGluR5 antagonist. Optimization of the modular scaffold led to the discovery of 16m, a compound with high affinity for mGluR5 and excellent selectivity over other glutamate receptors. Compound 16m exhibits a favorable PK profile in rats, robust anxiolytic-like effects in three different animal models of fear and anxiety, as well as a good PK/PD correlation. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.001

文献信息

• Novel aryl- and heteroarylpiperazines
  申请人：——

  公开号：US20030236259A1

  公开（公告）日：2003-12-25

  Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.

  小说芳基和杂环芳基哌嗪，这些化合物的药物组成物的使用，包含这些化合物的药物组成物，以及使用这些化合物和组成物的治疗方法。这些化合物显示出高度和选择性的结合亲和力，表明组胺H3受体拮抗，反向激动剂或激动剂活性。因此，这些化合物对于治疗与组胺H3受体相关的疾病和障碍非常有用。
• Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity
  作者：Carsten Spanka、Ralf Glatthar、Sandrine Desrayaud、Markus Fendt、David Orain、Thomas Troxler、Ivo Vranesic

  DOI：10.1016/j.bmcl.2009.11.001

  日期：2010.1

  High throughput screening led to the identification of nicotinamide derivative 2 as a structurally novel mGluR5 antagonist. Optimization of the modular scaffold led to the discovery of 16m, a compound with high affinity for mGluR5 and excellent selectivity over other glutamate receptors. Compound 16m exhibits a favorable PK profile in rats, robust anxiolytic-like effects in three different animal models of fear and anxiety, as well as a good PK/PD correlation. (C) 2009 Elsevier Ltd. All rights reserved.
• Novel Aryl- and Heteroarylpiperazines
  申请人：Hohlweg Rolf

  公开号：US20090264435A1

  公开（公告）日：2009-10-22

  Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.

  新型芳基和杂环基哌嗪，这些化合物的药用组合物，包含这些化合物的药用组合物，以及采用这些化合物和组合物的治疗方法。这些化合物表现出高度和选择性的结合亲和力，表明它们具有组胺H3受体拮抗、反向激动或激动活性。因此，这些化合物对于治疗与组胺H3受体相关的疾病和障碍非常有用。