N-(7-amino-3-bromo-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)acetamide | 934293-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(7-amino-3-bromo-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)acetamide
• CAS: 934293-56-8
• 化学式: C₁₄H₁₂BrN₅O
• 分子量: 346.186
• InChiKey: JERAKHJPSWDRNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  85.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Pyrazolopyrimidines as protein kinase inhibitors
  申请人：Paruch Kamil

  公开号：US20070082902A1

  公开（公告）日：2007-04-12

  In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了一种新型的吡唑并[1,5-a]嘧啶类化合物，作为蛋白质和/或检查点激酶的抑制剂，制备这种化合物的方法，包括一种或多种这样的化合物的制药组合物，制备包括一种或多种这样的化合物的制药配方的方法，以及使用这样的化合物或制药组合物治疗、预防、抑制或改善与蛋白质或检查点激酶相关的一种或多种疾病的方法。
• PYRAZOLO(1, 5A) PYRIMIDINES AS PROTEIN KINASE INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1931675B1

  公开（公告）日：2015-01-14
• US7645762B2
  申请人：——

  公开号：US7645762B2

  公开（公告）日：2010-01-12
• [EN] PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS<br/>[FR] PYRAZOLOPYRIMIDINES UTILISEES COMME INHIBITEURS DE LA PROTEINE KINASE
  申请人：SCHERING CORP

  公开号：WO2007044407A2

  公开（公告）日：2007-04-19

  [EN] In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
  [FR] Dans ces nombreux modes de réalisation, l'invention concerne une nouvelle classe de composés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs des protéines kinases et/ou des kinases de point de contrôle, des procédés de préparation de ces composés, des compositions pharmaceutiques comprenant un ou plusieurs desdits composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs desdits composés et des méthodes de traitement, de prévention, d'inhibition ou d'amélioration d'une ou plusieurs maladie(s) associée(s) aux protéines kinases ou aux kinases de point de contrôle au moyen des composés ou des compositions pharmaceutiques.