2-((2-iodophenyl)amino)-2-phenylethan-1-ol | 1486476-90-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-((2-iodophenyl)amino)-2-phenylethan-1-ol
• CAS: 1486476-90-7
• 化学式: C₁₄H₁₄INO
• 分子量: 339.176
• InChiKey: MFKDKLXOEAIFEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  17.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  32.26
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-((2-iodophenyl)amino)-2-phenylethan-1-ol 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 (1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene)gold(I) chloride 、 三乙胺 、 双三氟甲烷磺酰亚胺银盐 作用下， 以 甲苯 为溶剂， 反应 3.5h， 生成 1-Methyl-1,4-diphenyl-3,4-dihydro-[1,4]oxazino[4,3-a]indole
  参考文献：
  名称：

  通过金（I）催化级联反应新进入多环熔融吲哚

  摘要：

  金标准：用于制备多环稠合吲哚核的金催化级联反应序列利用了炔丙醇的易得性和化学灵活性。用水作为唯一的化学计量副产物，可以高收率获得所需的三环或四环化合物。

  DOI：

  10.1002/asia.201201249
• 作为产物：
  描述：

  氧化苯乙烯 、 2-碘苯胺 在 potassium phosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 36.0h， 以80%的产率得到2-((2-iodophenyl)amino)-2-phenylethan-1-ol
  参考文献：
  名称：

  通过金（I）催化级联反应新进入多环熔融吲哚

  摘要：

  金标准：用于制备多环稠合吲哚核的金催化级联反应序列利用了炔丙醇的易得性和化学灵活性。用水作为唯一的化学计量副产物，可以高收率获得所需的三环或四环化合物。

  DOI：

  10.1002/asia.201201249

文献信息

• Studies towards the Enantioselective Synthesis of Cryptowolinol via Pd0-Catalyzed C(sp3)–H Arylation/Parallel Kinetic Resolution
  作者：Takeru Miyakoshi、Domenic Kronenberg、Sota Tamaki、Rafael Lombardi、Olivier Baudoin

  DOI：10.1021/acs.orglett.4c00386

  日期：2024.4.19

  We report a model study towards the enantioselective synthesis of the dibenzopyrrocoline alkaloid (−)-cryptowolinol. The key step involves a challenging enantioselective Pd0-catalyzed C(sp3)–H arylation performed with a chiral NHC ligand, which proceeds via parallel kinetic resolution (PKR). A very efficient PKR process was achieved on a deoxygenated model substrate and was successfully transposed

  我们报告了二苯并吡咯啉生物碱 (−)-cryptowolinol 对映选择性合成的模型研究。关键步骤涉及使用手性 NHC 配体进行具有挑战性的对映选择性 Pd 0催化的 C(sp 3 )–H 芳基化，该反应通过平行动力学拆分 (PKR) 进行。在脱氧模型底物上实现了非常有效的 PKR 过程，并成功转变成 (−)-cryptowolinol 的潜在中间体。
• Graphene based magnetic nanohybrids as promising catalysts for the green synthesis of β-amino alcohol derivatives
  作者：Ankush Sheoran、Jaspreet Kaur、Paramdeep Kaur、Vinod Kumar、K.B. Tikoo、Jyoti Agarwal、S. Bansal、Sonal Singhal

  DOI：10.1016/j.molstruc.2019.127522

  日期：2020.3

  The principle of green chemistry evolves around designing products and processes with catalyst retrieval as its foremost aim. In this regard, the present report encompasses the synthesis of graphene based magnetic nanohybrids (CoFe@rGO) and their catalytic evaluation for epoxide ring opening reactions. Numerous techniques were employed for sample characterization. Powder X- Ray diffraction patterns confirm the single phase cubic structure corresponding to CoFe2O4 with Fd-3m space group. The average crystallite size was observed to be in the range of 8-12 nm for all the samples which was calculated in accordance with Debye-Scherrer equation. The FE-SEM and HR-TEM techniques were utilized to obtain detailed structural analysis of the nanohybrids displaying layered structure of GO decorated with CoFe2O4 nanoparticles. The EDX spectra confirm the elemental purity of the synthesized materials. Magnetic measurements were investigated by vibrating sample magnetometer, displaying the increase in saturation magnetization values with increase in CoFe2O4 concentration from 32.7 emu/g for CoFe@rGO (5%) to 38.6 emu/g for CoFe@rGO (20%). The catalytic presentation of the synthesized nanohybrids was evaluated for epoxide ring opening reactions under solvent free conditions displaying 100% conversion rates within 6 min of reaction time. (C) 2019 Elsevier B.V. All rights reserved.