4-[2-amino-4-(2-furyl)-5-pyrimidinyl]-1-ethyl-1,2-dihydro-2-pyridinone | 518354-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-[2-amino-4-(2-furyl)-5-pyrimidinyl]-1-ethyl-1,2-dihydro-2-pyridinone
• 英文别名: 4-[2-Amino-4-(furan-2-yl)pyrimidin-5-yl]-1-ethylpyridin-2-one
• CAS: 518354-42-2
• 化学式: C₁₅H₁₄N₄O₂
• 分子量: 282.302
• InChiKey: KETOEAABZAVRCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  85.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NOVEL MORPHOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES<br/>[FR] NOUVEAUX DERIVES DE MORPHOLINE, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：SANOFI SYNTHELABO

  公开号：WO2000058292A1

  公开（公告）日：2000-10-05

  L'invention concerne les composés de formule (I) ainsi que leurs sels avec des acides minéraux ou organiques, leurs solvats et/ou leurs hydrates, présentant une forte affinité et une grande sélectivité pour les récepteurs NK1 humains de la Substance P. L'invention concerne également leur procédé de préparation, les composés intermédiaires de formules (IV), (VI) et (VIII) utiles pour leur préparation, les compositions pharmaceutiques les contenant et leur utilisation pour la fabrication de médicaments destinés à traiter toute pathologie où la Substance P et/ou les récepteurs NK1 humains sont impliqués.

  本发明涉及具有式（I）的化合物及其与无机或有机酸的盐、它们的溶剂和/或水合物，具有强烈的亲和力和高选择性，可用于人类物质P的NK1受体。本发明还涉及它们的制备方法，用于它们的制备的式（IV）、（VI）和（VIII）的中间体化合物，包含它们的药物组合物及其用于制造药物以治疗任何涉及物质P和/或人类NK1受体的病理的用途。
• Pyrimidine compound and medicinal composition thereof
  申请人：Harada Hitoshi

  公开号：US20050004149A1

  公开（公告）日：2005-01-06

  The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A 1 , A 2A , A 2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. In the formula, R 1 and R 2 are the same as or different from each other and each represents a hydrogen atom, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a cycloalkenyl group having three to eight carbon atoms which may be substituted, a 5 to 14-membered non-aromatic heterocyclic group which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, an acyl group having one to six carbon atoms which may be substituted or an alkylsulfonyl group having one to six carbon atoms which may be substituted; R 3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, a nitrogen atom which may be substituted, an oxygen atom which may be substituted or a sulfur atom which may be substituted; R 4 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted or a 5 to 14-membered non-aromatic heterocyclic group having at least one or more unsaturated bonds which may be substituted; and R 5 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted or a 5 to 14-membered aromatic heterocyclic group which may be substituted.

  本发明提供了一种新型嘧啶化合物，具有优异的腺苷受体（A1、A2A、A2B受体）拮抗作用。更具体地，提供了下式所示的化合物、其盐或其溶剂化物。其中，R1和R2相同或不同，分别代表氢原子、可被取代的具有1至6个碳原子的烷基、可被取代的具有2至6个碳原子的烯基、可被取代的具有2至6个碳原子的炔基、可被取代的具有3至8个碳原子的环烷基、可被取代的具有3至8个碳原子的环烯基、可被取代的5至14个成员的非芳香杂环基、可被取代的具有6至14个碳原子的芳香烃环基、可被取代的5至14个成员的芳香杂环基、可被取代的具有1至6个碳原子的酰基或可被取代的具有1至6个碳原子的烷基磺酰基；R3代表氢原子、卤素原子、氰基、可被取代的具有1至6个碳原子的烷基、可被取代的具有2至6个碳原子的烯基、可被取代的具有2至6个碳原子的炔基、可被取代的具有6至14个碳原子的芳香烃环基、可被取代的5至14个成员的芳香杂环基、可被取代的氮原子、可被取代的氧原子或可被取代的硫原子；R4代表可被取代的具有6至14个碳原子的芳香烃环基、可被取代的5至14个成员的芳香杂环基或可被取代的具有至少一个或多个不饱和键的5至14个成员的非芳香杂环基；而R5代表可被取代的具有6至14个碳原子的芳香烃环基或可被取代的5至14个成员的芳香杂环基。
• PYRIMIDINE COMPOUNDS AND MEDICINAL COMPOSITION THEREOF
  申请人：Harada Hitoshi

  公开号：US20090030023A1

  公开（公告）日：2009-01-29

  A compound represented by the following formula (I), a salt, or a solvate thereof: wherein, R 1 and R 2 are the same as or different from each other and each represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a non-aromatic heterocyclic group, an aromatic hydrocarbon cyclic group, an aromatic heterocyclic group, an acyl group or an alkylsulfonyl group all of which may be substituted and wherein one, or both, of R 1 or R 2 is an aromatic, or non-aromatic, heterocyclic group which may be substituted; R 3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group, an alkenyl group, an alkynyl group, an aromatic hydrocarbon cyclic group, an aromatic heterocyclic group, a nitrogen atom, an oxygen atom or a sulfur atom all of which may be substituted if possible; and R 4 is a pyridyl group which may be substituted.

  以下是化合物（I）的化学式，盐或其溶剂化物： 其中，R1和R2相同或不同，每个代表氢原子，烷基，烯基，炔基，环烷基，环烯基，非芳香杂环基，芳香烃环基，芳香杂环基，酰基或烷基磺酰基，所有这些基团都可以被取代，其中R1或R2中的一个或两个是可能被取代的芳香或非芳香杂环基；R3代表氢原子，卤素原子，氰基，烷基，烯基，炔基，芳香烃环基，芳香杂环基，氮原子，氧原子或硫原子，所有这些基团都可以被取代；R4是可能被取代的吡啶基团。
• PYRIMIDINE COMPOUND AND MEDICINAL COMPOSITION THEREOF
  申请人：Eisai Co., Ltd.

  公开号：EP1439175A1

  公开（公告）日：2004-07-21

  The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. In the formula, R1 and R2 are the same as or different from each other and each represents a hydrogen atom, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a cycloalkenyl group having three to eight carbon atoms which may be substituted, a 5 to 14-membered non-aromatic heterocyclic group which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, an acyl group having one to six carbon atoms which may be substituted or an alkylsulfonyl group having one to six carbon atoms which may be substituted; R3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, a nitrogen atom which may be substituted, an oxygen atom which may be substituted or a sulfur atom which may be substituted; R4 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted or a 5 to 14-membered non-aromatic heterocyclic group having at least one or more unsaturated bonds which may be substituted; and R5 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted or a 5 to 14-membered aromatic heterocyclic group which may be substituted.

  本发明提供了一种新型嘧啶化合物，它具有优异的腺苷受体（A1、A2A、A2B 受体）拮抗作用。更具体地说，本发明提供了由下式代表的化合物、其盐或它们的溶液。 式中，R1 和 R2 彼此相同或不同，各自代表氢原子、具有一至六个碳原子且可被取代的烷基、具有二至六个碳原子且可被取代的烯基、具有二至六个碳原子且可被取代的炔基、具有三至八个碳原子且可被取代的环烷基、具有三至八个碳原子并可被取代的环烯基、具有五至十四个碳原子并可被取代的非芳香杂环基、具有六至十四个碳原子并可被取代的芳香烃环基、具有五至十四个碳原子并可被取代的芳香杂环基、具有一至六个碳原子并可被取代的酰基或具有一至六个碳原子并可被取代的烷基磺酰基；R3 代表氢原子、卤素原子、氰基、具有 1 至 6 个碳原子且可被取代的烷基、具有 2 至 6 个碳原子且可被取代的烯基、具有 2 至 6 个碳原子且可被取代的炔基、具有 6 至 14 个碳原子且可被取代的芳香烃环基、具有 5 至 14 个元的芳香杂环基、可被取代的氮原子、可被取代的氧原子或可被取代的硫原子；R4 代表具有 6 至 14 个碳原子的芳香烃环基（可被取代）、5 至 14 元芳香杂环基（可被取代）或具有至少一个或多个不饱和键的 5 至 14 元非芳香杂环基（可被取代）；以及 R5 代表具有 6 至 14 个碳原子的芳香烃环基（可被取代）或 5 至 14 元芳香杂环基（可被取代）。
• Pyrimidine compounds and medicinal composition thereof
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2246344A1

  公开（公告）日：2010-11-03

  The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them. In the formula, R1 and R2 are the same as or different from each other and each represents a hydrogen atom, an alkyl group having one to sixcarbon atoms which maybe substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, a cycloalkyl group having three to eight carbon atoms which may be substituted, a cycloalkenyl group having three to eight carbon atoms which may be substituted, a 5 to 14-membered non-aromatic heterocyclic group which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, an acyl group having one to six carbon atoms which may be substituted or an alkylsulfonyl group having one to six carbon atoms which may be substituted; R3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having one to six carbon atoms which may be substituted, an alkenyl group having two to six carbon atoms which may be substituted, an alkynyl group having two to six carbon atoms which may be substituted, an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted, a 5 to 14-membered aromatic heterocyclic group which may be substituted, a nitrogen atom which may be substituted, an oxygen atom which may be substituted or a sulfur atom which may be substituted; R4 represents a 4-pyridyl group which may have one or two substituents; and R5 represents an aromatic hydrocarbon cyclic group having six to fourteen carbon atoms which may be substituted or a 5 to 14-membered aromatic heterocyclic group which may be substituted.

  本发明提供了一种新型嘧啶化合物，它具有优异的腺苷受体（A1、A2A、A2B 受体）拮抗作用。更具体地说，本发明提供了由下式代表的化合物、其盐或它们的溶液。 式中，R1 和 R2 彼此相同或不同，各自代表氢原子、具有一至六个碳原子且可能被取代的烷基、具有二至六个碳原子且可能被取代的烯基、具有二至六个碳原子且可能被取代的炔基、具有三至八个碳原子且可能被取代的环烷基、具有三至八个碳原子并可被取代的环烯基、具有五至十四个碳原子并可被取代的非芳香杂环基、具有六至十四个碳原子并可被取代的芳香烃环基、具有五至十四个碳原子并可被取代的芳香杂环基、具有一至六个碳原子并可被取代的酰基或具有一至六个碳原子并可被取代的烷基磺酰基；R3 代表氢原子、卤素原子、氰基、具有 1 至 6 个碳原子且可被取代的烷基、具有 2 至 6 个碳原子且可被取代的烯基、具有 2 至 6 个碳原子且可被取代的炔基、具有 6 至 14 个碳原子且可被取代的芳香烃环基、具有 5 至 14 个元的芳香杂环基、可被取代的氮原子、可被取代的氧原子或可被取代的硫原子；R4 代表可具有一个或两个取代基的 4-吡啶基；以及 R5 代表可被取代的具有 6 至 14 个碳原子的芳香烃环基或可被取代的 5 至 14 元芳香杂环基。