32,37-bis(3-bromobenzyl)-12,15,18-trioxa-1,8,22,29,32,37-hexaazatetracyclo[27.5.5.1^3,7.1^23,27]hentetraconta-3(41),4,6,23(40),24,26-hexaene | 1352942-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 32,37-bis(3-bromobenzyl)-12,15,18-trioxa-1,8,22,29,32,37-hexaazatetracyclo[27.5.5.1^3,7.1^23,27]hentetraconta-3(41),4,6,23(40),24,26-hexaene
• 英文别名: 32,37-Bis[(3-bromophenyl)methyl]-12,15,18-trioxa-1,8,22,29,32,37-hexazatetracyclo[27.5.5.13,7.123,27]hentetraconta-3(41),4,6,23,25,27(40)-hexaene
• CAS: 1352942-34-7
• 化学式: C₄₆H₆₂Br₂N₆O₃
• 分子量: 906.845
• InChiKey: JXYNFNNOCAQSQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  57
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  4,7,10-三氧-1,13-十三烷二胺 、 32,37-bis(3-bromobenzyl)-12,15,18-trioxa-1,8,22,29,32,37-hexaazatetracyclo[27.5.5.1^3,7.1^23,27]hentetraconta-3(41),4,6,23(40),24,26-hexaene 在 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 sodium t-butanolate 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以33%的产率得到12,15,18,43,46,49-hexaoxa-1,8,22,29,32,39,53,60-octaazaheptacyclo[30.30.2.2^29,60.13,7.1^23,27.1^34,38.1^54,58]heptaconta-3(70),4,6,23(69),24,26,34(68),35,37,54(67),55,57-dodecaene
  参考文献：
  名称：

  Pd-catalyzed amination in the synthesis of cyclen-based macrotricycles

  摘要：

  Three approaches to three types of cyclen-based macrotricycles have been elaborated starting from trans-bis(3-bromobenzyl)cyclen. The macrotricycles were synthesized via Pd-catalyzed amination. The first approach employed consecutive macrocyclization and benzylation steps giving a cage-like tricycle. In the second, cyclen amino groups were Boc-protected prior to formation of the second and the third rings. In the third method, macrotricycles were synthesized according to a one-step procedure using diazacrown ethers. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.024
• 作为产物：
  描述：

  4,7,10-三氧-1,13-十三烷二胺 在 potassium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 sodium t-butanolate 作用下， 以 1,4-二氧六环 、 乙腈 为溶剂， 反应 48.0h， 生成 32,37-bis(3-bromobenzyl)-12,15,18-trioxa-1,8,22,29,32,37-hexaazatetracyclo[27.5.5.1^3,7.1^23,27]hentetraconta-3(41),4,6,23(40),24,26-hexaene
  参考文献：
  名称：

  Pd-catalyzed amination in the synthesis of cyclen-based macrotricycles

  摘要：

  Three approaches to three types of cyclen-based macrotricycles have been elaborated starting from trans-bis(3-bromobenzyl)cyclen. The macrotricycles were synthesized via Pd-catalyzed amination. The first approach employed consecutive macrocyclization and benzylation steps giving a cage-like tricycle. In the second, cyclen amino groups were Boc-protected prior to formation of the second and the third rings. In the third method, macrotricycles were synthesized according to a one-step procedure using diazacrown ethers. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.024

文献信息

• Macrobicyclic and Macrotricyclic Derivatives of N,N’,N’’,N’’’-Tetrasubstituted Cyclen and Cyclam
  作者：Irina P. Beletskaya、Alexei D. Averin、Sergei M. Kobelev、Alexei K. Buryak、Andrei I. Vovk、Valerii P. Kukhar、Franck Denat、Roger Guilard

  DOI：10.3987/com-14-s(k)71

  日期：——

  N,N',N '',N'''-Tetrabenzyl derivatives of cyclen and cyclam possessing two bromine atoms in trans-positioned phenyl rings were introduced in the Pd-catalyzed amination reactions with oxadiamines and polyamines to provide a wide series of macrobicyclic compounds with tetrabenzyl substituted cyclen and cyclam central moieties in yields up to 31%. Macrocycles based on 1,7-dibenzylcyclen were modified with two 3-bromobenzyl substituents and introduced in the Pd-catalyzed macrocyclization with di- and trioxadiamines to afford spherically shaped macrotricyclic cryptands in yields up to 33%. An alternative approach to isomeric macrotricyclic cryptands employed Pd-catalyzed amination of di(Boc)-di(3-bromobenzyl)cyclen followed by the dialkylation of the resulting bicycle with two bromobenzyl groups and final catalytic macrocyclization step (yields up to 24%).