7-hydroxy-4-methyl-6-palmitoyl-coumarin | 859324-45-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-hydroxy-4-methyl-6-palmitoyl-coumarin
• 英文别名: 7-Hydroxy-4-methyl-6-palmitoyl-cumarin；6-Hexadecanoyl-4-methylumbelliferone；6-hexadecanoyl-7-hydroxy-4-methylchromen-2-one
• CAS: 859324-45-1
• 化学式: C₂₆H₃₈O₄
• 分子量: 414.585
• InChiKey: OYIZLJAXZMCNSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  30
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-hydroxy-4-methyl-6-palmitoyl-coumarin 在 盐酸 、 amalgamated zinc 作用下， 生成 6-hexadecyl-7-hydroxy-4-methyl-coumarin
  参考文献：
  名称：

  Kansara; Shah, Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1948, vol. 17/3 A, p. 57,60

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(2,4-二羟基苯基)-十六烷-1-酮 、 乙酰乙酸乙酯 在 三氯氧磷 、 苯 作用下， 生成 7-hydroxy-4-methyl-6-palmitoyl-coumarin
  参考文献：
  名称：

  Kansara; Shah, Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1948, vol. 17/3 A, p. 57,60

  摘要：

  DOI：

文献信息

• Enzymatic Assays Using Umbelliferone Substrates with Cyclodextrins in Droplets of Oil
  申请人：Winger Theodore

  公开号：US20110118132A1

  公开（公告）日：2011-05-19

  The invention is directed to droplet actuator devices and assay methods. The method may include, among other things, a method of conducting enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil, the method including incubating a droplet in oil, the droplet preferably comprising an umbelliferone substrate, a sample, and a cyclodextrin compound. The methods may further include a method of substantially eliminating cross-contamination between droplets in enzymatic containing substrate-based bioassays. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate for stabilizing the substrate within an aqueous environment, wherein the inclusion complex may be formed using cyclodextrins. In yet another embodiment, the invention may provide a method of enhancing hydrolysis of enzymatic substrates. The methods may further include a method of forming an inclusion complex with the substrate for stabilizing the substrate within an aqueous environment, wherein the substrate may be a 4-MU- or HMU containing substrate. The inclusion complex may be formed using cyclodextrin.

  本发明涉及液滴操纵器件和测定方法。该方法可能包括使用环糊精在油滴中使用香豆素底物进行酶促反应的方法，该方法包括在油中孵育油滴，油滴优选包括香豆素底物，样品和环糊精化合物。该方法还可以包括在基于底物的生物测定中实现减少液滴间交叉污染的方法。该方法可能包括固定酶促底物，包括与底物形成包含复合物以稳定底物在水环境中，其中可以使用环糊精形成包含复合物。在另一种实施方式中，本发明可能提供一种增强酶促底物水解的方法。该方法还可以包括与底物形成包含复合物以稳定底物在水环境中，其中底物可以是含4-MU或HMU的底物。包含复合物可以使用环糊精形成。
• Method of hydrolyzing an enzymatic substrate
  申请人：Winger Theodore

  公开号：US20120136147A1

  公开（公告）日：2012-05-31

  The invention is directed to droplet actuator devices and assay methods. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate within an aqueous environment in contact with an oil.

  这项发明涉及液滴操作器件和检测方法。该方法可能包括将酶底物固定，包括在与油接触的水环境中形成与底物的包含物复合物。
• Method of Conducting an Assay
  申请人：Advanced Liquid Logic, Inc.

  公开号：US20140141460A1

  公开（公告）日：2014-05-22

  The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.

  这项发明涉及液滴驱动器装置和测定方法。该发明包括进行测定的测定方法，其中将样品与香豆素衍生物结合，其中样品可能包含能够切割香豆素衍生物的酶，并且香豆素衍生物包括一个或多个修饰基团修饰的香豆素核心。
• Enzyme Assays on a Droplet Actuator
  申请人：ADVANCED LIQUID LOGIC, INC.

  公开号：US20150184219A1

  公开（公告）日：2015-07-02

  The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.

  本发明涉及液滴驱动器装置和检测方法。本发明包括检测方法，用于进行检测，包括将样品与香豆素衍生物结合，其中样品可能包含能够裂解香豆素衍生物的酶，并且香豆素衍生物包括经过一个或多个修饰基修饰的香豆素核心。
• ENZYME ASSAYS ON A DROPLET ACTUATOR
  申请人：Advanced Liquid Logic, Inc.

  公开号：EP2516669A2

  公开（公告）日：2012-10-31