Nitroketoprofen | 156970-83-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Nitroketoprofen
• 英文别名: 4-nitrooxybutyl 2-(3-benzoylphenyl)propanoate
• CAS: 156970-83-1
• 化学式: C20H21NO6
• 分子量: 371.4
• InChiKey: DRBPAHMAGAOWNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  98.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Oral pharmaceutical forms of liquid drugs having improved bioavailability
  申请人：Macelloni Cristina

  公开号：US20060171969A1

  公开（公告）日：2006-08-03

  The present invention relates to new pharmaceutical compositions for the administration of liquid drugs in solid oral forms, said compositions comprising one or more active ingredients, one or more surface-active agents and optionally a co-surfactant and/or an absorption enhancer absorbed on a solid inert carrier.

  本发明涉及以固体口服形式给药液体药物的新型药物组合物，所述组合物包括一种或多种活性成分、一种或多种表面活性剂，以及可选的辅助表面活性剂和/或吸收促进剂，吸收在固体惰性载体上。
• ORAL PHARMACEUTICAL FORMS OF LIQUID DRUGS HAVING IMPROVED BIOAVAILABILITY
  申请人：Nicox S.A.

  公开号：EP1526839A1

  公开（公告）日：2005-05-04
• PHARMACEUTICAL FORMULATION OF NITROOXYDERIVATIVES OF NSAIDS
  申请人：Gasslander Ulla

  公开号：US20090203759A1

  公开（公告）日：2009-08-13

  The present invention relates to a pharmaceutical formulation comprising: a) one or more NO-releasing NSAID(s) of formula (I); b) one or more surfactants; c) a carbonyl scavenger compound selected from free acid forms, salts, carboxylic acid esters derivatives of a compound of formula (II) H 2 N—(CH 2 ) m —(C 6 H 4 )—COOH  (II) wherein m=0-10; and d) optionally an oil or semi-solid fat and/or a short-chain alcohol.
• US8691869B2
  申请人：——

  公开号：US8691869B2

  公开（公告）日：2014-04-08
• [EN] ORAL PHARMACEUTICAL FORMS OF LIQUID DRUGS HAVING IMPROVED BIOAVAILABILITY<br/>[FR] FORMES PHARMACEUTIQUES ORALES DE MEDICAMENTS LIQUIDES A BIODISPONIBILITE AMELIOREE
  申请人：NICOX SA

  公开号：WO2004000273A1

  公开（公告）日：2003-12-31

  The present invention relates to new pharmaceutical compositions for the administration of liquid drugs in solid oral forms, said compositions comprising one or more active ingredients, one or more surface-active agents and optionally a co-surfactant and/or an absorption enhancer absorbed on a solid inert carrier.