2-{(tert-Butyl-dimethyl-silanyloxy)-[5-(tert-butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-methyl}-4-methoxymethoxy-phenol | 855303-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-{(tert-Butyl-dimethyl-silanyloxy)-[5-(tert-butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-methyl}-4-methoxymethoxy-phenol
• CAS: 855303-20-7
• 化学式: C₃₁H₅₄O₅Si₂
• 分子量: 562.938
• InChiKey: PNERIJZFBBHUQE-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-{(tert-Butyl-dimethyl-silanyloxy)-[5-(tert-butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-methyl}-4-methoxymethoxy-phenol 在 咪唑 、 叔丁基过氧化氢 、 bis(acetylacetonate)oxovanadium 、 四丁基氟化铵 、 potassium carbonate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 乙腈 、 苯 为溶剂， 生成 (1S,5S)-8-(methoxymethoxy)-15,18,18-trimethyl-2,4,12-trioxatetracyclo[12.3.1.01,5.06,11]octadeca-6(11),7,9,14-tetraen-3-one
  参考文献：
  名称：

  Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

  摘要：

  We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.038
• 作为产物：
  描述：

  2-(tert-Butyl-dimethyl-silanyloxy)-5-methoxymethoxy-benzaldehyde 、 以 四氢呋喃 为溶剂， 生成 [2-(tert-Butyl-dimethyl-silanyloxy)-5-methoxymethoxy-phenyl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-methanol 、 2-{(tert-Butyl-dimethyl-silanyloxy)-[5-(tert-butyl-dimethyl-silanyloxymethyl)-4,6,6-trimethyl-cyclohexa-1,4-dienyl]-methyl}-4-methoxymethoxy-phenol
  参考文献：
  名称：

  Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

  摘要：

  We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.038