(E)-3-(3,4-diphenylbut-2-en-2-yl)thiophene | 1427179-79-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-3-(3,4-diphenylbut-2-en-2-yl)thiophene
• 英文别名: 3-[(E)-3,4-diphenylbut-2-en-2-yl]thiophene
• CAS: 1427179-79-0
• 化学式: C₂₀H₁₈S
• 分子量: 290.429
• InChiKey: QYYKPQOIEIBMRL-CAPFRKAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(3-Thienyl)propanoic acid 在 4-二甲氨基吡啶 、 叔丁基锂 、 N,N'-二环己基碳二亚胺 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 正戊烷 为溶剂， 反应 34.0h， 生成 (E)-3-(3,4-diphenylbut-2-en-2-yl)thiophene
  参考文献：
  名称：

  Stereoselective Synthesis of All-Carbon Tetrasubstituted Alkenes from In Situ Generated Ketenes and Organometallic Reagents

  摘要：

  Stereoselective synthesis of tetrasubstituted alkenes is a challenging problem in chemical synthesis. New protocols to access this Important, yet simple, structural motif are of fundamental significance because they are found In many valuable molecules and can be utilized in a variety of Important complexity building chemical transformations. The two-step strategy presented herein involves stereoselective generation of an alkenyl pseudohalide followed by a stereospecific metal-catalyzed cross-coupling.

  DOI：

  10.1021/ol400392r

文献信息

• Stereoselective Synthesis of All-Carbon Tetrasubstituted Alkenes from In Situ Generated Ketenes and Organometallic Reagents
  作者：Wei You、Yan Li、M. Kevin Brown

  DOI：10.1021/ol400392r

  日期：2013.4.5

  Stereoselective synthesis of tetrasubstituted alkenes is a challenging problem in chemical synthesis. New protocols to access this Important, yet simple, structural motif are of fundamental significance because they are found In many valuable molecules and can be utilized in a variety of Important complexity building chemical transformations. The two-step strategy presented herein involves stereoselective generation of an alkenyl pseudohalide followed by a stereospecific metal-catalyzed cross-coupling.