Ethyl 2,2-Dichloro-3-methylcyclopropanethiocarboxylate | 155193-23-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硫代羧酸及其衍生物
• 英文名称: Ethyl 2,2-Dichloro-3-methylcyclopropanethiocarboxylate
• 英文别名: O-ethyl 2,2-dichloro-3-methylcyclopropane-1-carbothioate
• CAS: 155193-23-0
• 化学式: C₇H₁₀Cl₂OS
• 分子量: 213.128
• InChiKey: JMIJJSHOXIYMCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  41.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  丙烯腈 、 Ethyl 2,2-Dichloro-3-methylcyclopropanethiocarboxylate 在 Bis-(trimethylzinn)-benzpinakolat 作用下， 以 苯 为溶剂， 反应 4.0h， 生成 Ethyl c-5-cyano-3,3-dichloro-t-2-methylcyclopentane-r-thiocarboxylate 、 Ethyl t-5-cyano-3,3-dichloro-t-2-methylcyclopentane-r-thiocarboxylate
  参考文献：
  名称：

  Thioamide and Thioester Cyclopentane Synthesis via Trimethyltin Radical Catalyzed Alkenylation of Substituted (Thiocarbonyl)cyclopropanes

  摘要：

  Thioamide cyclopropanes bearing phenyl substituents and thioamide- or thioester cyclopropanes bearing gem-dichloro and methyl substituents were subjected to trimethyltin radical catalyzed alkenylation to furnish the corresponding substituted (thiocarbonyl)cyclopentanes. The stereochemical outcome of these transformations can be rationalized by considering the effects of substituents, upon cyclization of the intermediate functionalized 5-hexenyl radicals.

  DOI：

  10.1021/jo00084a035
• 作为产物：
  描述：

  ester ethylique de l'acide methyl-2 dichloro-3,3 cyclopropanoique 在 2,4-双(苯硫基)-1,3-二硫杂-2,4-二磷杂环丁烷 2,4-二硫化物 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以46%的产率得到Ethyl 2,2-Dichloro-3-methylcyclopropanethiocarboxylate
  参考文献：
  名称：

  Thioamide and Thioester Cyclopentane Synthesis via Trimethyltin Radical Catalyzed Alkenylation of Substituted (Thiocarbonyl)cyclopropanes

  摘要：

  Thioamide cyclopropanes bearing phenyl substituents and thioamide- or thioester cyclopropanes bearing gem-dichloro and methyl substituents were subjected to trimethyltin radical catalyzed alkenylation to furnish the corresponding substituted (thiocarbonyl)cyclopentanes. The stereochemical outcome of these transformations can be rationalized by considering the effects of substituents, upon cyclization of the intermediate functionalized 5-hexenyl radicals.

  DOI：

  10.1021/jo00084a035

文献信息

• Thioamide and Thioester Cyclopentane Synthesis via Trimethyltin Radical Catalyzed Alkenylation of Substituted (Thiocarbonyl)cyclopropanes
  作者：Ken S. Feldman、Klaas Schildknegt

  DOI：10.1021/jo00084a035

  日期：1994.3

  Thioamide cyclopropanes bearing phenyl substituents and thioamide- or thioester cyclopropanes bearing gem-dichloro and methyl substituents were subjected to trimethyltin radical catalyzed alkenylation to furnish the corresponding substituted (thiocarbonyl)cyclopentanes. The stereochemical outcome of these transformations can be rationalized by considering the effects of substituents, upon cyclization of the intermediate functionalized 5-hexenyl radicals.