3-chloro-1-(2-nitrophenyl)-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-4-methylazetidin-2-one | 1397263-26-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 3-chloro-1-(2-nitrophenyl)-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-4-methylazetidin-2-one
• 英文别名: 3-chloro-4-[2-(2-chloroquinolin-3-yl)-5-pyridin-4-yl-2H-1,3,4-oxadiazol-3-yl]-4-methyl-1-(2-nitrophenyl)azetidin-2-one
• CAS: 1397263-26-1
• 化学式: C₂₆H₁₈Cl₂N₆O₄
• 分子量: 549.373
• InChiKey: YBEISRVMTLKHTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N’-((2-chloroquinolin-3-yl)methylene)isonicotinohydrazide 在 溶剂黄146 、 三乙胺 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 2.5h， 生成 3-chloro-1-(2-nitrophenyl)-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-4-methylazetidin-2-one
  参考文献：
  名称：

  Synthesis, Characterization, and Antimicrobial Evaluation of Quinoline-Oxadiazole–Based Azetidinone Derivatives

  摘要：

  A series of 3-chloro-1-(aryl)-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-4-ethyl-azetidin-2-ones (5a-l) have been synthesized and characterized by IR, H-1 NMR, and C-13 NMR. Synthesized compounds were screened for their antimicrobial activity against different strains of bacteria (E. coli, P. aeruginosa, S. aureus, S. pyogenes, C. albicans, A. niger, and A. clavatus). On the basis of statistical analysis, it has been observed that compounds had significant correlations.

  DOI：

  10.1080/00397911.2011.580199

文献信息

• Synthesis, Characterization, and Antimicrobial Evaluation of Quinoline-Oxadiazole–Based Azetidinone Derivatives
  作者：Amit M. Dodiya、Niraj R. Shihory、N. C. Desai

  DOI：10.1080/00397911.2011.580199

  日期：2012.11

  A series of 3-chloro-1-(aryl)-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-4-ethyl-azetidin-2-ones (5a-l) have been synthesized and characterized by IR, H-1 NMR, and C-13 NMR. Synthesized compounds were screened for their antimicrobial activity against different strains of bacteria (E. coli, P. aeruginosa, S. aureus, S. pyogenes, C. albicans, A. niger, and A. clavatus). On the basis of statistical analysis, it has been observed that compounds had significant correlations.