α-1-naphthalenyl-[1,1'-biphenyl]-4-methanol | 147022-35-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-1-naphthalenyl-[1,1'-biphenyl]-4-methanol
• 英文别名: Biphenyl-4-yl-[1]naphthyl-methanol；(+/-)-Hydroxy-(naphthyl-(1))-(biphenylyl-(4))-methan；Biphenyl-4-yl(1-naphthyl)methanol；naphthalen-1-yl-(4-phenylphenyl)methanol
• CAS: 147022-35-3
• 化学式: C₂₃H₁₈O
• 分子量: 310.395
• InChiKey: ARBHZWPCQBMLCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  α-1-naphthalenyl-[1,1'-biphenyl]-4-methanol 、 双(咪唑-1-基)亚砜 以 乙腈 为溶剂， 以42%的产率得到1-[1-Naphthyl-(4-phenylphenyl)methyl]imidazole
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j
• 作为产物：
  描述：

  [1,1'-biphenyl]-4-yl(naphthalen-1-yl)methanone 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以97%的产率得到α-1-naphthalenyl-[1,1'-biphenyl]-4-methanol
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j

文献信息

• Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation
  作者：Soobin Lim、Hyungdo Cho、Jongheon Jeong、Minjae Jang、Hyunseok Kim、Seung Hwan Cho、Eunsung Lee

  DOI：10.1021/acs.orglett.0c02752

  日期：2020.9.18

  cheap electrophilic silicon source with magnesium. This method is compatible with various silicon sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic silicon source.

  碳-氟键的过渡金属催化转化不仅解决了一个有趣的难题，即具有挑战性的键激活，而且还提供了新的合成策略，其中相对惰性的CF键转换为通用的官能团。在本文中，我们报告了使用便宜的亲电硅源和镁的芳基氟化物的钴催化的甲硅烷基化反应。该方法与各种硅源兼容，可以在有氧条件下运行。机理研究支持格氏试剂的原位形成，该试剂被亲电子硅源捕获。
• STUDIES ON MOLECULAR-REARRANGEMENTS OF α-GLYCOLS. VIII. REDUCTION OF αβ-DINAPHTHYL KETONE (AN ATTEMPT TO COMPARE THE ELECTRO NEGATIVITIES OF α- AND β- NAPHTHYL RADICALS)
  作者：Masao Migita

  DOI：10.1246/bcsj.8.22

  日期：1933.1
• Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers
  作者：M Artico、G Stefancich、R Silvestri、S Massa、G Apuzzo、M Artico、G Simonetti

  DOI：10.1016/0223-5234(92)90089-j

  日期：1992.10

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.