3,6,9,12-tetraazadodecan-1-ol | 38361-85-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,6,9,12-tetraazadodecan-1-ol
• 英文别名: 2-{[2-({2-[(2-Aminoethyl)amino]ethyl}amino)ethyl]amino}ethan-1-ol；2-[2-[2-(2-aminoethylamino)ethylamino]ethylamino]ethanol
• CAS: 38361-85-2
• 化学式: C₈H₂₂N₄O
• 分子量: 190.289
• InChiKey: YTSNVWMTVVGZTI-UHFFFAOYSA-N

物化性质

• 沸点：
  347.6±27.0 °C(Predicted)
• 密度：
  1.010±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  13
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  82.3
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,6,9,12-tetraazadodecan-1-ol 在 盐酸 作用下， 生成 1-chloro-3,6,9,12-tetraazadodecane tetrahydrochloride
  参考文献：
  名称：

  Bobylev, V. A.; Chechik, V. O., Journal of general chemistry of the USSR, 1990, vol. 60, # 12.1, p. 2438 - 2442

  摘要：

  DOI：
• 作为产物：
  描述：

  N1-[2-(1-氮丙啶基)乙基]-1,2-乙二胺 、 C.I.酸性橙108 在 盐酸 作用下， 以 水 为溶剂， 以53%的产率得到3,6,9,12-tetraazadodecan-1-ol
  参考文献：
  名称：

  Bobylev, V. A.; Chechik, V. O., Journal of general chemistry of the USSR, 1990, vol. 60, # 12.1, p. 2438 - 2442

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR MANUFACTURING CHAIN-EXTENDED HYDROXYETHYLETHYLENEAMINES, ETHYLENEAMINES, OR MIXTURES THEREOF<br/>[FR] PROCÉDÉ DE FABRICATION D'HYDROXYÉTHYLÉTHYLÈNEAMINES À CHAÎNE ÉTENDUE, D'ÉTHYLÈNEAMINES OU DE MÉLANGES DE CELLES-CI
  申请人：AKZO NOBEL CHEMICALS INT BV

  公开号：WO2018166938A1

  公开（公告）日：2018-09-20

  The invention pertains to a process for preparing hydroxyethylethyleneamines, ethyleneamines, or mixtures thereof, and/or ethylene urea derivatives thereof comprising the step of reacting diethanolamine with an amine-functional compound comprising at least two –NH-units of which at least one is selected from the group of primary amine groups and cyclic secondary amine groups, the amine-functional compound comprising at least one –NH-CH2-CH2-NH-unit wherein one or more -NH- CH2-CH2-NH-units in the amine-functional compound may be present in the form of cyclic ethylene urea moieties, piperazine moieties, or linear ethylene urea moieties, in the presence of a carbon oxide delivering agent, wherein -the molar ratio of amine-functional compound to diethanolamine is at least 0.2:1, and -the molar ratio of carbon oxide delivering agent to –NH-CH2-CH2-NH-units in the amine-functional compound is at least 0.1:1. The invention makes it possible to obtain higher hydroxyethylethyleneamines, ethyleneamines, or mixtures thereof, and/or ethylene urea derivatives thereof from diethanolamine, which is an attractive starting material.

  该发明涉及一种制备羟乙基乙烯胺、乙烯胺或二者的混合物，和/或其乙烯脲衍生物的过程，包括将二乙醇胺与一种含有至少两个-NH-基团的胺基化合物反应的步骤，其中至少一个选自一次胺基团和环状二次胺基团的组中，该胺基化合物包括至少一个-NH-CH2- -NH-基团，其中该胺基化合物中的一个或多个-NH- - -NH-基团可以以环状乙烯脲基团、哌嗪基团或线性乙烯脲基团的形式存在，存在一种碳氧化物传递剂的情况下，其中-胺基化合物与二乙醇胺的摩尔比至少为0.2:1，和-碳氧化物传递剂与胺基化合物中的-NH- - -NH-基团的摩尔比至少为0.1:1。该发明使得从二乙醇胺中获得更高的羟乙基乙烯胺、乙烯胺或二者的混合物，和/或其乙烯脲衍生物成为可能，而二乙醇胺是一种有吸引力的起始原料。
• ISOMERIZATION OF OLEFINIC COMPOUNDS
  申请人：BASF SE

  公开号：US20140051889A1

  公开（公告）日：2014-02-20

  The present invention relates to a process for preparing an olefinically unsaturated phosphonium salt having at least two olefinic double bonds, of which one double bond has a Z or cis conformation and the second or a further double bond an E conformation, from an olefinically unsaturated phosphonium salt having at least two olefinic double bonds of different configuration compared to the target compound, and both especially have an all-E or all-trans conformation. In addition, the invention provides for the use of the compound obtained by the process for provision of terpenoid substances as medicaments.

  本发明涉及一种制备至少具有两个烯丙基双键的烯丙基未饱和膦盐的方法，其中一个双键具有Z或顺式构象，第二个或进一步的双键具有E构象，从至少具有两个与目标化合物不同构象的烯丙基未饱和膦盐中制备。此外，本发明还提供了通过该方法获得的化合物用于作为药物提供萜类物质的用途。
• [EN] TWO-STEP PROCESS FOR CONVERTING CYCLIC ALKYLENE UREAS INTO THEIR CORRESPONDING ALKYLENE AMINES<br/>[FR] PROCÉDÉ EN DEUX ÉTAPES DE CONVERSION D'ALKYLÈNE-URÉES CYCLIQUES EN LEURS ALKYLÈNE-AMINES CORRESPONDANTES
  申请人：AKZO NOBEL CHEMICALS INT BV

  公开号：WO2019030193A1

  公开（公告）日：2019-02-14

  The invention pertains to a process for converting cyclic alkyleneureas into their corresponding alkyleneamines, comprising - in a first step converting cyclic alkyleneureas into their corresponding alkyleneamines by reacting cyclic alkyleneureas in the liquid phase with water with removal of CO2, so as to convert between 5 mole% and 95 mole% of alkyleneurea moieties in the feedstock to the corresponding amines, and - in a second step adding an inorganic base and reacting cyclic alkylene ureas remaining from the first step with the inorganic base to convert them partially or completely into their corresponding alkyleneamines. It has been found that the two-step process of the present invention makes it possible to still obtain a high conversion of cyclic alkyleneureas, while using substantially less strong inorganic base. The process according to the invention also shows a higher selectivity to amines than the prior art process.

  本发明涉及一种将环状烷基脲转化为相应的烷基胺的过程，包括以下步骤：第一步，在液相中通过与水反应并去除CO2将环状烷基脲转化为相应的烷基胺，以将进料中的5摩尔％至95摩尔％的烷基脲转化为相应的胺；第二步，加入无机碱并将第一步剩余的环状烷基脲与无机碱反应，部分或完全将其转化为相应的烷基胺。发现本发明的两步法使得仍然可以获得高度转化的环状烷基脲，同时使用的强碱明显较少。本发明的过程还表现出比现有技术更高的胺选择性。
• [EN] PROCESS FOR CONVERTING CYCLIC ALKYLENE UREAS INTO THEIR CORRESPONDING ALKYLENE AMINES<br/>[FR] PROCÉDÉ DE CONVERSION D'ALKYLÈNE-URÉES CYCLIQUES EN LEURS ALKYLÈNE-AMINES CORRESPONDANTES
  申请人：AKZO NOBEL CHEMICALS INT BV

  公开号：WO2019030196A1

  公开（公告）日：2019-02-14

  The invention relates to a process for converting one or more cyclic ethylene ureas into corresponding ethylene amines and carbon dioxide. In the process, water is contacted with one or more cyclic alkylene urea compounds comprising one or more cyclic alkylene urea moieties in a reaction vessel at a temperature of 150 to 400°C, optionally in the presence of an amine compound selected from the group of primary amines, cyclic secondary amines and bicyclic tertiary amines. The mole ratio of water to cyclic alkylene urea moieties is in the range of from 0.1 to 20. In the reaction, at least a portion of the cyclic alkylene urea moieties are converted to corresponding alkylenediamine moieties and carbon dioxide, and the carbon dioxide is removed from the liquid reaction mixture in a stripping vessel by feeding a stripping fluid to the stripping vessel, and removing a carbon dioxide-containing stripping fluid.

  该发明涉及一种将一个或多个环状乙烯脲转化为相应的乙烯胺和二氧化碳的过程。在该过程中，将水与一个或多个含有一个或多个环状烷基脲基团的环状烯烃脲化合物在反应容器中接触，温度为150至400°C，可选地在存在选择自一级胺、环状二级胺和双环三级胺组的胺化合物的情况下。水与环状烷基脲基团的摩尔比在0.1至20的范围内。在反应中，至少部分环状烷基脲基团被转化为相应的烯二胺基团和二氧化碳，二氧化碳通过向脱除器提供脱除流体，并移除含有二氧化碳的脱除流体从液体反应混合物中去除。
• [EN] PROCESS FOR CONVERTING CYCLIC ALKYLENEUREAS INTO THEIR CORRESPONDING ALKYLENEAMINES<br/>[FR] PROCÉDÉ DE CONVERSION D'ALKYLÈNE-URÉES CYCLIQUES EN LEURS ALKYLÈNE-AMINES CORRESPONDANTES
  申请人：AKZO NOBEL CHEMICALS INT BV

  公开号：WO2019030192A1

  公开（公告）日：2019-02-14

  The present invention is directed to a process for converting cyclic alkyleneureas into their corresponding alkyleneamines wherein a feedstock comprising cyclic alkyleneureas is reacted in the liquid phase with water in an amount of 0. -20 mole water per mole urea moiety, at a temperature of at least 230°C, with removal of CO2. It has been found that the process according to the invention allows the efficient conversion of alkyleneureas into the corresponding alkyleneamines. The process has a high yield and low side product production. It is preferred for the cyclic alkyleneurea to comprises one or more of EU (ethyleneurea, the urea derivative of ethylenediamine (EDA)), UDETA (the urea derivative of diethylenetriamine (DETA)), UTETA (the group of urea derivatives of triethylenetetraamine (TETA), DUTETA (the diurea derivative of triethylenetetramine), UTEPAs (the urea derivatives of tetraethylenpentamine (TEPA)), DUTEPAs (the diurea derivatives of TEPA), or urea derivatives of pentaethylenehexamine (PEHA) and higher analogues, UAEEA (the urea derivative of aminoethylethanolannine), HE-UDETA (the urea derivative of hydroxyethyl diethylenetriamine), HE-UTETA (the urea derivative of hydroxyethyl triethylenetetraamine, HE-DUTETA (the diurea derivative of hydroxyethyl triethylenetetraamine), or any mixture of these.

  本发明涉及一种将环烷基脲转化为相应的烷基胺的方法，其中包括在液相中将含有环烷基脲的原料与水反应，水的量为每摩尔脲基团0. -20摩尔，反应温度至少为230°C，并去除CO2。发现该发明的方法能够高效地将烷基脲转化为相应的烷基胺。该过程产率高，副产物产量低。最好的环烷基脲包括EU（乙烯脲，乙二胺（EDA）的脲衍生物）、UDETA（二乙烯三胺（DETA）的脲衍生物）、UTETA（三乙烯四胺（TETA）的脲衍生物群）、DUTETA（三乙烯四胺的二脲衍生物）、UTEPAs（四乙烯五胺（TEPA）的脲衍生物）、DUTEPAs（TEPA的二脲衍生物）或五乙烯六胺（PEHA）的脲衍生物及更高类似物、UAEEA（氨基乙基乙醇胺的脲衍生物）、HE-UDETA（羟乙基二乙烯三胺的脲衍生物）、HE-UTETA（羟乙基三乙烯四胺的脲衍生物）、HE-DUTETA（羟乙基三乙烯四胺的二脲衍生物）或其中任意混合物。