(6R)-7-(1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimldazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4,4-difluoro-L-prolyl)-6-methyl-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane | 1235576-32-5

• 分子结构分类: 有机化合物
• 英文名称: (6R)-7-(1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimldazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4,4-difluoro-L-prolyl)-6-methyl-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane
• 英文别名: (6R)-7-(1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4,4-difluoro-L-prolyl)-6-methyl-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane；1-[(6R)-7-[(2S)-1-[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-4,4-difluoropyrrolidine-2-carbonyl]-6-methyl-4,7-diazaspiro[2.5]octan-4-yl]-2,2,2-trifluoroethanone
• CAS: 1235576-32-5
• 化学式: C₃₅H₃₄Cl₂F₆N₆O₃S
• 分子量: 803.656
• InChiKey: TYGWRJUAUGOYFT-WBACJXCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  53
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• Imidazothiazole Derivatives Having Proline Ring Structure
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20130172362A1

  公开（公告）日：2013-07-04

  Compounds that inhibit interaction between murine double minute 2 (Mdm2) protein and p53 protein and that exhibit anti-tumor activity are provided. Compounds provided by the present disclosure include imidazothiazole derivatives that inhibit interaction between Mdm2 protein and p53 protein and exhibit anti-tumor activity.

  本文提供了抑制小鼠双分子2（Mdm2）蛋白与p53蛋白相互作用并表现出抗肿瘤活性的化合物。本文提供的化合物包括咪唑噻唑衍生物，其抑制Mdm2蛋白与p53蛋白相互作用并表现出抗肿瘤活性。
• IMIDAZOTHIAZOLE DERIVATIVE HAVING PROLINE RING STRUCTURE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2380892A1

  公开（公告）日：2011-10-26

  [Problem to be Solved] There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. [Solution] The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R1 R2, R3, R4, R5, R6, R7, Ar1, and Ar2 in formula (1) respectively have the same meanings as defined in the specification.

  [有待解决的问题］ 有一种新型化合物可抑制小鼠双分 2（Mdm2）蛋白和 p53 蛋白之间的相互作用，并具有抗肿瘤活性。 [解决方案］ 本发明提供了一种由下式（1）表示的咪唑噻唑衍生物，该衍生物具有各种取代基，可抑制 Mdm2 蛋白和 p53 蛋白之间的相互作用，并具有抗肿瘤活性： 其中，式（1）中的 R1 R2、R3、R4、R5、R6、R7、Ar1 和 Ar2 分别与说明书中定义的含义相同。
• US8404691B2
  申请人：——

  公开号：US8404691B2

  公开（公告）日：2013-03-26