Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.
本文公开了新的环二核苷酸化合物和组合物及其作为药物治疗疾病的应用。还提供了调节对疾病的免疫反应、诱导干扰素
基因刺激器(STING)依赖性 I 型干扰素产生以及人或动物体内共调
基因的方法,用于治疗癌症等疾病,特别是转移性实体瘤和淋巴瘤、炎症、过敏性和自身免疫性疾病、传染性疾病,以及用作抗病毒剂和疫苗佐剂。