2,3-dihydro-2,3-dimethyl-2,3-epoxybenzofuran | 135831-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 2,3-dihydro-2,3-dimethyl-2,3-epoxybenzofuran
• CAS: 135831-49-1
• 化学式: C₁₀H₁₀O₂
• 分子量: 162.188
• InChiKey: KBEHMFHMCJJWBP-NXEZZACHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  12.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.76
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2,3-dihydro-2,3-dimethyl-2,3-epoxybenzofuran 在 L-蛋氨酸 、 水 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以90%的产率得到2,3-Dihydro-2,3-dimethylbenzofuran-2,3-diol
  参考文献：
  名称：

  Chemical model studies on the mutagenesis of benzofuran dioxetanes in the Ames test: evidence for the benzofuran epoxide as ultimate mutagen

  摘要：

  The synthesis of the first benzofuran epoxide 3a was achieved by epoxidation of the benzofuran 1a with dimethyldioxirane and alternatively by deoxygenation of the benzofuran dioxetane 2a with sulfides. This labile epoxide formed with nucleophiles such as water, methanol, thiophenol, and imidazole the corresponding adducts 13a-16a. In contrast to epoxide 3a, the dioxetanes 2 required acid catalysis (CF3CO2H) for the addition of water, methanol, and azide ion to give the corresponding adducts 9-11; in the absence of nucleophiles the allylic hydroperoxides 8 were formed. The decomposition of benzofuran dioxetanes 2 in the polar, protic solvents water and methanol afforded not only expected cleavage products 4 but also the 1,3-dioxols 5, the spiroepoxide dimer 6a, and the 1,4-dioxines 7. An intramolecular electron-transfer mechanism is postulated for the formation of the spiroepoxide, which subsequently dimerizes to 6a or rearranges into 5 and 7. Only the benzofuran epoxide 3a, besides the benzofuran dioxetanes 2, was mutagenic in the Salmonella typhimurium strain TA100. Therefore, we implicate the epoxide 3a as the ultimate mutagen responsible for the high mutagenic activity observed with dioxetane 2a in the Ames test. We postulate that in the oxidative metabolism of polycyclic arenes and heteroarenes the corresponding epoxides are generated from the intermediary dioxetanes by deoxygenation with sulfides.

  DOI：

  10.1021/ja00021a029
• 作为产物：
  描述：

  2,3-二甲基苯呋喃 在 二甲基二环氧乙烷 作用下， 以 丙酮 为溶剂， 反应 2.5h， 以100%的产率得到2,3-dihydro-2,3-dimethyl-2,3-epoxybenzofuran
  参考文献：
  名称：

  Chemical model studies on the mutagenesis of benzofuran dioxetanes in the Ames test: evidence for the benzofuran epoxide as ultimate mutagen

  摘要：

  The synthesis of the first benzofuran epoxide 3a was achieved by epoxidation of the benzofuran 1a with dimethyldioxirane and alternatively by deoxygenation of the benzofuran dioxetane 2a with sulfides. This labile epoxide formed with nucleophiles such as water, methanol, thiophenol, and imidazole the corresponding adducts 13a-16a. In contrast to epoxide 3a, the dioxetanes 2 required acid catalysis (CF3CO2H) for the addition of water, methanol, and azide ion to give the corresponding adducts 9-11; in the absence of nucleophiles the allylic hydroperoxides 8 were formed. The decomposition of benzofuran dioxetanes 2 in the polar, protic solvents water and methanol afforded not only expected cleavage products 4 but also the 1,3-dioxols 5, the spiroepoxide dimer 6a, and the 1,4-dioxines 7. An intramolecular electron-transfer mechanism is postulated for the formation of the spiroepoxide, which subsequently dimerizes to 6a or rearranges into 5 and 7. Only the benzofuran epoxide 3a, besides the benzofuran dioxetanes 2, was mutagenic in the Salmonella typhimurium strain TA100. Therefore, we implicate the epoxide 3a as the ultimate mutagen responsible for the high mutagenic activity observed with dioxetane 2a in the Ames test. We postulate that in the oxidative metabolism of polycyclic arenes and heteroarenes the corresponding epoxides are generated from the intermediary dioxetanes by deoxygenation with sulfides.

  DOI：

  10.1021/ja00021a029