4-[7-(isopropylamino)-2-methyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde | 1240469-62-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-[7-(isopropylamino)-2-methyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde
• 英文别名: 4-[2-Methyl-6-phenyl-7-(propan-2-ylamino)-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]benzaldehyde
• CAS: 1240469-62-8
• 化学式: C₂₂H₂₁N₅O
• 分子量: 371.442
• InChiKey: ZAVMTBURYXSTLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  72.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• FUSED PYRIMIDINES
  申请人：Bayer Intellectual Property GmbH

  公开号：EP2396330B1

  公开（公告）日：2016-04-06
• US8957064B2
  申请人：——

  公开号：US8957064B2

  公开（公告）日：2015-02-17
• [EN] FUSED PYRIMIDINES<br/>[FR] PYRIMIDINES CONDENSÉES
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2010091808A1

  公开（公告）日：2010-08-19

  Compounds of formula (I), or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.