N,N'-bis(p-methylbenzyl)piperazine | 73535-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-bis(p-methylbenzyl)piperazine
• 英文别名: 1,4-bis-(4-methyl-benzyl)-piperazine；1,4-Bis-(4-methyl-benzyl)-piperazin；1,4-Bis[(4-methylphenyl)methyl]piperazine
• CAS: 73535-69-0
• 化学式: C₂₀H₂₆N₂
• 分子量: 294.44
• InChiKey: ZEHFQNKRGQYSJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-[[(4-甲基苯基)甲基]氨基]-乙醇 在 dichloro(pentamethylcyclopentadienyl) iridium 、 碳酸氢钠 作用下， 以 甲苯 为溶剂， 反应 17.0h， 以45%的产率得到N,N'-bis(p-methylbenzyl)piperazine
  参考文献：
  名称：

  Synthesis of Piperazine Derivatives by Cp*Ir Complex-Catalyzed N-Alkylative Reactions of Ethanolamines

  摘要：

  DOI：

  10.3987/com-08-s(f)77

文献信息

• Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis
  作者：Vishwas G. Chandrashekhar、Wolfgang Baumann、Matthias Beller、Rajenahally V. Jagadeesh

  DOI：10.1126/science.abn7565

  日期：2022.6.24

  Efficient and general methods for the synthesis of amines remain in high demand in the chemical industry. Among the many known processes, catalytic hydrogenation is a cost-effective and industrially proven reaction and currently used to produce a wide array of such compounds. We report a homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic

  合成胺的有效和通用方法在化学工业中仍然有很高的需求。在许多已知的方法中，催化加氢是一种经济有效且经工业验证的反应，目前用于生产多种此类化合物。我们报告了一种均相镍催化剂，用于将一系列芳族、杂芳族和脂肪族腈与伯胺和仲胺或氨进行氢化交叉偶联。该通用氢化方案通过直接和高选择性合成 > 230 种功能化和结构多样的胺（包括药学相关和手性产物）以及15N-同位素标记应用。
• Morren et al., Bulletin des Societes Chimiques Belges, 1951, vol. 60, p. 282,288
  作者：Morren et al.

  DOI：——

  日期：——
• Derivatives of Piperazine. VI. Alkylation by Means of Aldehydes
  作者：W. T. Forsee、C. B. Pollard

  DOI：10.1021/ja01313a010

  日期：1935.10
• UNSYMMETRICAL CYANINE DIMER COMPOUNDS AND THEIR APPLICATION
  申请人：Yue Stephen

  公开号：US20080199875A1

  公开（公告）日：2008-08-21

  Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA.
• US4264770A
  申请人：——

  公开号：US4264770A

  公开（公告）日：1981-04-28