2-(4-bromophenyl)-2-phenyl-1-aminoethane | 1075799-24-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-bromophenyl)-2-phenyl-1-aminoethane
• 英文别名: 2-(4-Bromophenyl)-2-phenylethanamine
• CAS: 1075799-24-4
• 化学式: C₁₄H₁₄BrN
• 分子量: 276.176
• InChiKey: UFQBLLHPZKGJGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-bromophenyl)-2-phenyl-1-aminoethane 在 盐酸 作用下， 以 乙醚 为溶剂， 以0.290 g的产率得到2-(4-bromophenyl)-2-phenyl-1-aminoethane hydrochloride
  参考文献：
  名称：

  Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT_2A Receptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis and Receptor Modeling Investigation

  摘要：

  The effects of 3-position substitution of 9-aminomethyl-9,10-dihydroanthracene (AMDA) on 5-HT2A receptor affinity were determined and compared to a parallel series of DOB-like 1-(2,5-dimethoxyphenyl)-2-aminopropanes substituted at the 4-position. The results were interpreted within the context of 5-HT2A receptor models that suggest that members of the DOB-like series call bind to the receptor in two distinct modes that correlate with the compounds' functional activity. Automated ligand docking and molecular dynamics suggest that all of the AMDA derivatives, the parent of which is a 5-HT2A antagonist, bind in a fashion analogous to that for the sterically demanding antagonist DOB-like compounds. The failure of the F340(6.52)L mutation to adversely affect the affinity of AMDA and the 3-bromo derivative is consistent with the proposed modes of orientation. Evaluation of ligand-receptor complex models suggest that a valine/threonine exchange between the 5-HT2A and D-2 receptors may be the origin of selectivity for AMDA and two substituted derivatives.

  DOI：

  10.1021/jm800771x
• 作为产物：
  描述：

  2-(4-溴苯基)-2-苯基乙腈 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 2-(4-bromophenyl)-2-phenyl-1-aminoethane
  参考文献：
  名称：

  Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT_2A Receptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis and Receptor Modeling Investigation

  摘要：

  The effects of 3-position substitution of 9-aminomethyl-9,10-dihydroanthracene (AMDA) on 5-HT2A receptor affinity were determined and compared to a parallel series of DOB-like 1-(2,5-dimethoxyphenyl)-2-aminopropanes substituted at the 4-position. The results were interpreted within the context of 5-HT2A receptor models that suggest that members of the DOB-like series call bind to the receptor in two distinct modes that correlate with the compounds' functional activity. Automated ligand docking and molecular dynamics suggest that all of the AMDA derivatives, the parent of which is a 5-HT2A antagonist, bind in a fashion analogous to that for the sterically demanding antagonist DOB-like compounds. The failure of the F340(6.52)L mutation to adversely affect the affinity of AMDA and the 3-bromo derivative is consistent with the proposed modes of orientation. Evaluation of ligand-receptor complex models suggest that a valine/threonine exchange between the 5-HT2A and D-2 receptors may be the origin of selectivity for AMDA and two substituted derivatives.

  DOI：

  10.1021/jm800771x

文献信息

• NEUROPROTECTANT AGENTS
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0573548A1

  公开（公告）日：1993-12-15
• [EN] NEUROPROTECTANT AGENTS
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：WO1992014813A1

  公开（公告）日：1992-09-03

  (EN) This invention involves novel neuroprotectant agents of formula (I), in which R1 and R3 are, independently, hydrogen, cyano, nitro, halo or perhaloalkyl, with the proviso that one of R1 and R3 is other than hydrogen; R2 is alkyl; or a pharmaceutically acceptable salt thereof, processes for preparing them, compositions containing them and their use as NMDA antagonists.(FR) L'invention se rapporte à de nouveaux agents neuroprotecteurs, représentés par la formule (I), où R1 et R3 représentent séparément hydrogène, cyano, nitro, halo ou perhaloalkyle, à condition que l'un des éléments R1 et R3 représente une fonction autre que l'hydrogène; R2 représente alkyle; ou à un sel pharmaceutiquement acceptable de ces agents, à des procédés servant à leur préparation, à des compositions contenant ces agents et à leur utilisation comme antagonistes de la N-méthyl-D-aspartate (NMDA).
• Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT_2A Receptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis and Receptor Modeling Investigation
  作者：Scott P. Runyon、Philip D. Mosier、Bryan L. Roth、Richard A. Glennon、Richard B. Westkaemper

  DOI：10.1021/jm800771x

  日期：2008.11.13

  The effects of 3-position substitution of 9-aminomethyl-9,10-dihydroanthracene (AMDA) on 5-HT2A receptor affinity were determined and compared to a parallel series of DOB-like 1-(2,5-dimethoxyphenyl)-2-aminopropanes substituted at the 4-position. The results were interpreted within the context of 5-HT2A receptor models that suggest that members of the DOB-like series call bind to the receptor in two distinct modes that correlate with the compounds' functional activity. Automated ligand docking and molecular dynamics suggest that all of the AMDA derivatives, the parent of which is a 5-HT2A antagonist, bind in a fashion analogous to that for the sterically demanding antagonist DOB-like compounds. The failure of the F340(6.52)L mutation to adversely affect the affinity of AMDA and the 3-bromo derivative is consistent with the proposed modes of orientation. Evaluation of ligand-receptor complex models suggest that a valine/threonine exchange between the 5-HT2A and D-2 receptors may be the origin of selectivity for AMDA and two substituted derivatives.