1-pyrenecarboxylic acid hydrazide | 32089-54-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 1-pyrenecarboxylic acid hydrazide
• 英文别名: pyrene-1-carbohydrazide；1-pyrenecarbohydrazide
• CAS: 32089-54-6
• 化学式: C₁₇H₁₂N₂O
• 分子量: 260.295
• InChiKey: VLRKTIXKKUGTNT-UHFFFAOYSA-N

物化性质

• 密度：
  1.373±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-pyrenecarboxylic acid hydrazide 在 copper(II) perchlorate hexahydrate 、 水 作用下， 以 乙腈 为溶剂， 反应 0.17h， 生成 1-芘甲酸
  参考文献：
  名称：

  基于金属诱导的carb碳酰肼水解的Cu 2 +-选择性开启荧光信号

  摘要：

  我们开发了一种基于1-pyrenecarbohydrazide（1）水解为1-pyrene羧酸的简单的Cu 2 +-选择性开启荧光信号探针。探头1表现出突出的荧光的Cu信令2+在10％的离子水Tris缓冲的（pH 7.0）中的DMSO溶液与5.93×10的检测极限-8  M.信令与来自pyreneacetic酸和芘丁酸表明衍生对照化合物随着酰肼官能团与the荧光团之间距离的增加，荧光信号减弱。在实际应用中，该探针用于测定模拟半导体废水中的Cu 2+。

  DOI：

  10.1016/j.tetlet.2017.06.038
• 作为产物：
  描述：

  1-芘甲酸 在 肼 作用下， 以 甲醇 为溶剂， 生成 1-pyrenecarboxylic acid hydrazide
  参考文献：
  名称：

  A novel pyrene-based fluorescent probe for the rapid and efficient detection of Co2+ in HeLa cells and natural water samples

  摘要：

  Excessive levels of Co2+ in the environment can cause serious diseases to humans and affect the growth of crops. Therefore, it is necessary to develop effective methods for monitoring Co2+. In the present work, a novel, low-toxic fluorescent probe, PEPA, for the rapid and efficient detection of Co2+ is synthesized. PEPA shows high sensitivity, with a limit of detection of 0.104 mu M and a fast response to Co2+ (<4 min). The detection mechanism was confirmed by FT-IR. HRMS and DFT calculations. Co2+ can restrict the free rotation of the C=N group and the pyrazine ring of PEPA, resulting in the enhancement of fluorescence. In addition, the recognition process of Co2+ can be realized with the naked eye (i.e., a color change from colorless to blue fluorescence). The successful detection of Co2+ in test strips and environmental water samples provides strong support for its application potential. Interestingly, the recovery rate of Co2+ detected by PEPA can reach 93% after being recovered four times. Importantly, PEPA was suitable for the fluorescence imaging of exogenous Co2+ in HeLa cells. (C) 2020 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molliq.2020.112680

文献信息

• Benzothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines: Synthesis, Characterization, Antimicrobial Activity, and Incorporation into Solid Lipid Nanoparticles
  作者：Shridhar I. Panchamukhi、Jameel Ahmed S. Mulla、Nitinkumar S. Shetty、Mohammed Iqbal A. Khazi、Ashraf Y. Khan、Mallikarjun B. Kalashetti、Imitiyaz Ahmed M. Khazi

  DOI：10.1002/ardp.201000227

  日期：2011.6

  from the corresponding 2‐amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐3‐carbonitrile. These precursors were intern prepared by employing the Gewald's reaction. All the newly synthesized compounds were characterized by spectral and analytical data. Title compounds displayed promising antibacterial and antifungal activities. Compound 3h which exhibited good antimicrobial activity was incorporated into SLN

  由相应的 2-氨基-4,5,6,7-四氢苯并[b]噻吩-3-腈制备稠合三唑噻吩并嘧啶。这些前体是通过使用 Gewald 反应在内部制备的。所有新合成的化合物都通过光谱和分析数据进行表征。标题化合物显示出有希望的抗菌和抗真菌活性。将表现出良好抗菌活性的化合物 3h 掺入到 SLN 中，并对其粒度、包封率 (EE%)、扫描电子显微镜 (SEM)、差示扫描量热法 (DSC) 和体外释放研究进行表征。它显示出窄的粒径分布和高的截留效率。负载化合物的 SLN 在 pH 7.4 磷酸盐缓冲液中的体外释放研究，
• Controlling enzyme reactions by supramolecular protection and deprotection of oligosaccharide substrates
  作者：Milad Zangiabadi、Yan Zhao

  DOI：10.1039/d2cc03239b

  日期：——

  absent in enzymatic reactions. We here report supramolecular protective receptors that outcompete an enzyme in the binding of oligosaccharides. The strong binding inhibits the enzymatic reaction and addition of an even stronger ligand for the receptor releases the substrate. These receptors could be used to control products from the same substrate/enzyme mixture and regulate enzymatic reactions reversibly

  保护/去保护是复杂有机分子全合成中的一种强有力的策略，但在酶促反应中几乎没有类似的工具。我们在这里报告了在寡糖结合中胜过酶的超分子保护受体。强结合抑制酶促反应，并且为受体添加甚至更强的配体释放底物。这些受体可用于控制来自相同底物/酶混合物的产物并可逆地调节酶促反应。
• US8772044B2
  申请人：——

  公开号：US8772044B2

  公开（公告）日：2014-07-08