2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-ethylamino]-3-fluoro-2-fluoromethyl-propan-1-ol | 228547-72-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-ethylamino]-3-fluoro-2-fluoromethyl-propan-1-ol
• CAS: 228547-72-6
• 化学式: C₁₈H₃₁F₂NO₂Si
• 分子量: 359.532
• InChiKey: WAKKILQRLSBRFS-INIZCTEOSA-N

反应信息

• 作为反应物：
  描述：

  2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-ethylamino]-3-fluoro-2-fluoromethyl-propan-1-ol 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以100%的产率得到2-Amino-3-fluoro-2-fluoromethyl-propan-1-ol; hydrochloride
  参考文献：
  名称：

  Improved syntheses of fluorinated tertiary butylamines

  摘要：

  Two new and efficient methods using cyclic sulfamidate and nitrone chemistry were developed for the synthesis of the sterically congested 1,1-dimethyt-2-fluoroethylamine (1), 2-fluoro-1-(fluoromethyl)-1-methyl ethylamine (2) and 2-fluoro-1,1-bis-(fluoromethyl)-ethylamine (3). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00633-4
• 作为产物：
  描述：

  3-Fluoro-2-fluoromethyl-2-((R)-2-hydroxy-1-phenyl-ethylamino)-propionic acid methyl ester 在 咪唑 、 lithium aluminium tetrahydride 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 19.0h， 生成 2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-ethylamino]-3-fluoro-2-fluoromethyl-propan-1-ol
  参考文献：
  名称：

  Improved syntheses of fluorinated tertiary butylamines

  摘要：

  Two new and efficient methods using cyclic sulfamidate and nitrone chemistry were developed for the synthesis of the sterically congested 1,1-dimethyt-2-fluoroethylamine (1), 2-fluoro-1-(fluoromethyl)-1-methyl ethylamine (2) and 2-fluoro-1,1-bis-(fluoromethyl)-ethylamine (3). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00633-4