4-((4-cyano-5,6-diphenylpyridazin-3-yl)amino)-N-(phenylcarbamoyl)benzenesulfonamide | 1438435-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-((4-cyano-5,6-diphenylpyridazin-3-yl)amino)-N-(phenylcarbamoyl)benzenesulfonamide
• CAS: 1438435-67-6
• 化学式: C₃₀H₂₂N₆O₃S
• 分子量: 546.609
• InChiKey: DWTBXHBGINQUGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.94
• 重原子数：
  40.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  136.87
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  4-(4-cyano-5, 6-diphenylpyridazin-3-ylamino)benzene sulfonamide 、 异氰酸苯酯 在 potassium hydroxide 作用下， 以 苯 为溶剂， 反应 6.0h， 以86.6%的产率得到4-((4-cyano-5,6-diphenylpyridazin-3-yl)amino)-N-(phenylcarbamoyl)benzenesulfonamide
  参考文献：
  名称：

  Pyridazine and its related compounds. Part 34. Hypoglycemic and hypolipidemic activity of some novel condensed pyridazine sulfonamides

  摘要：

  A novel class of sulfonylurea and thiourea derivatives substituted with pyridazine and triazolopyridazine were designed and synthesized. The target compounds were assayed for their effects on the insulin release of alloxan-induced diabetic rats. The results showed that derivatives 4a, 4c, 8a, 11a, and 11b have significant antihyperglycemic effect in an experimental model of diabetes mellitus. No significant differences in cholesterol levels were observed between the diabetic group and diabetic groups that received the test compounds. However, the triglycerides level was reduced significantly by compound 8a when compared with the diabetic group.

  DOI：

  10.1007/s00044-013-0605-5