3-chloro-4-(hydroxymethyl)-1,4-dimethylimidazolidin-2-one | 1310681-26-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-chloro-4-(hydroxymethyl)-1,4-dimethylimidazolidin-2-one
• CAS: 1310681-26-5
• 化学式: C₆H₁₁ClN₂O₂
• 分子量: 178.619
• InChiKey: ZKUKLPIJLOJPOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(hydroxymethyl)-1,4-dimethylimidazolidin-2-one 在 次氯酸叔丁酯 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以55%的产率得到3-chloro-4-(hydroxymethyl)-1,4-dimethylimidazolidin-2-one
  参考文献：
  名称：

  Novel N-chloroheterocyclic antimicrobials

  摘要：

  Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.035

文献信息

• Substituted N,N-dihaloamines as antimicrobials
  申请人：Jain Rakesh K.

  公开号：US09248117B2

  公开（公告）日：2016-02-02

  The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.

  本申请描述了I式化合物，这些化合物是抗微生物剂，包括抗菌剂、消毒剂、抗真菌剂、杀菌剂和/或抗病毒剂。
• [EN] ANTIMICROBIAL POLYETHER AND POLYOL COMPOUNDS<br/>[FR] COMPOSÉS POLYÉTHER ET POLYOL ANTIMICROBIENS
  申请人：NOVABAY PHARMACEUTICALS INC

  公开号：WO2012054521A8

  公开（公告）日：2012-08-30
• ANTIMICROBIAL POLYETHER AND POLYOL COMPOUNDS
  申请人：NovaBay Pharmaceuticals, Inc.

  公开号：EP2629607A2

  公开（公告）日：2013-08-28
• Antimicrobial Polyether and Polyol Compounds
  申请人：Jain Rakesh K.

  公开号：US20120129793A1

  公开（公告）日：2012-05-24

  The present application describes compounds of Formula I and Formula IA and as disclosed herein, that are useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.
• US9248117B2
  申请人：——

  公开号：US9248117B2

  公开（公告）日：2016-02-02