hopeaphenol decaacetate | 107850-41-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: hopeaphenol decaacetate
• CAS: 107850-41-9
• 化学式: C₇₆H₆₂O₂₂
• 分子量: 1327.32
• InChiKey: KYCBAIUMHJCTFV-SEFVXWDNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.63
• 重原子数：
  98.0
• 可旋转键数：
  15.0
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  281.46
• 氢给体数：
  0.0
• 氢受体数：
  22.0

反应信息

• 作为产物：
  描述：

  hopeaphenol 、 乙酸酐 在 吡啶 作用下， 生成 hopeaphenol decaacetate
  参考文献：
  名称：

  Antitumor agents 200.1 cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives

  摘要：

  Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values of 0.6, 0.7 and 2.0 mu g/mL against KB, 1A9 and MCF-7 cells, respectively. Hopeaphenol (10) and pallidol hexaacetate (13) also showed significant cytotoxicity against KB cells with ED50 values of 1.2 and 1.6 mu g/mL, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00520-x