[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](4-iodophenyl)-methanone | 406162-04-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: [2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](4-iodophenyl)-methanone
• 英文别名: [2-chloro-4-(3-chlorophenyl)quinazolin-6-yl]-(4-iodophenyl)methanone
• CAS: 406162-04-7
• 化学式: C₂₁H₁₁Cl₂IN₂O
• 分子量: 505.142
• InChiKey: JNBKRGIQLKGKGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](4-iodophenyl)-methanone 在 sodium azide 作用下， 以 水 、 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 为溶剂， 以0.25 g (49%)的产率得到[5-(3-chlorophenyl)tetrazolo[1,5-a]quinazolin-7-yl](4-iodophenyl)-methanone
  参考文献：
  名称：

  Farnesyl transferase inhibiting 6-(substituted phenyl) Methy)-quinoline and quinazoline derinazoline derivaties

  摘要：

  这项发明包括具有法尼醇转移酶抑制活性的式(I)的新化合物，其中r、s、t、Y1—Y2、R1、R2、R3、R4、R5、R6和R7具有定义的含义；它们的制备、含有它们的组合物以及它们作为药物的用途。

  公开号：

  US20040048882A1
• 作为产物：
  描述：

  4-(3-chlorophenyl)-6-(4-iodobenzoyl)-2(1H)-quinazolinone 以 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 、 三氯氧磷 为溶剂， 以4.25 g (82%)的产率得到[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](4-iodophenyl)-methanone
  参考文献：
  名称：

  Farnesyl transferase inhibiting 6-(substituted phenyl) Methy)-quinoline and quinazoline derinazoline derivaties

  摘要：

  这项发明包括具有法尼醇转移酶抑制活性的式(I)的新化合物，其中r、s、t、Y1—Y2、R1、R2、R3、R4、R5、R6和R7具有定义的含义；它们的制备、含有它们的组合物以及它们作为药物的用途。

  公开号：

  US20040048882A1

文献信息

• [EN] FARNESYL TRANSFERASE INHIBITING TRICYCLIC QUINAZOLINE DERIVATIVES SUBSTITUTED WITH CARBON-LINKED IMIDAZOLES OR TRIAZOLES<br/>[FR] DERIVES DE QUINAZOLINE TRICYLIQUE INHIBANT LA FARNESYL TRANSFERASE SUBSTITUES AVEC DES IMIDAZOLES OU DES TRIAZOLES A LIAISON CARBONE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2003087101A1

  公开（公告）日：2003-10-23

  This invention comprises the novel compounds of formula (I) wherein r, s, t, R1, R2, R3, R4, R5, and R6 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

  本发明涉及具有法尼醇转移酶抑制活性的新型化合物，其化学结构式为(I)，其中r、s、t、R1、R2、R3、R4、R5和R6具有定义的含义；其制备方法、含有它们的组合物以及它们作为药物的用途。
• [EN] FARNESYL TRANSFERASE INHIBITING 6-[(SUBSTITUTED PHENYL)METHYL]-QUINOLINE AND QUINAZOLINE DERIVATIVES<br/>[FR] DERIVES DE LA QUINOLEINE ET DE LA QUINAZOLINE 6-[(PHENYLE SUBSTITUE)METHYLE] INHIBITEURS DE LA FARNESYLE TRANSFERASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2002024683A1

  公开（公告）日：2002-03-28

  This invention comprises the novel compounds of formula (I)wherein r, s, t, Y?1-Y2, R1, R2, R3, R4, R5, R6 and R7¿ have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

  本发明涉及具有法尼醇转移酶抑制活性的新型化合物，其化学式为(I)，其中r、s、t、Y1-Y2、R1、R2、R3、R4、R5、R6和R7具有定义的含义；以及其制备、含有它们的组合物以及它们作为药物的用途。
• Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles of triazoles
  申请人：Angibaud Rene Patrick

  公开号：US20050148609A1

  公开（公告）日：2005-07-07

  This invention comprises the novel compounds of formula (I) wherein r, s, t, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

  本发明涉及式（I）的新化合物，其中r，s，t，R1，R2，R3，R4，R5和R6具有定义的含义，具有法尼醇转移酶抑制活性；它们的制备，含有它们的组合物以及它们作为药物的用途。
• Aryl and heteroaryl compounds, compositions and methods of use
  申请人：Mjalli M.M. Adnan

  公开号：US20050049310A1

  公开（公告）日：2005-03-03

  This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. The compounds of Formula (I) may activate an erythropoietin receptor and thus, may be useful to induce red blood cell production. The compounds of Formula (I) and compositions including compounds of Formula (I) may be useful in a variety of applications including the management, treatment and/or control of diseases caused at least in part by deficient (or inefficient) EPO production relative to hemoglobin level.

  本发明提供了式（I）所述的芳基和杂环芳基化合物，以及其制备方法。还提供了使用式（I）化合物制备的药物组合物以及制备此类组合物的方法。式（I）化合物可以激活促红细胞生成素受体，因此可能有助于诱导红细胞生成。式（I）化合物和包括式（I）化合物的组合物可以用于各种应用，包括管理、治疗和/或控制由于相对于血红蛋白水平缺乏（或低效）促红细胞生成素产生而引起的疾病。
• Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives
  申请人：Janssen Pharmaceutica N.V.

  公开号：US07173040B2

  公开（公告）日：2007-02-06

  This invention comprises the compounds of formula (I): wherein r, s, t, Y1–Y2, R1, R2, R3, R4, R5, R6 and R7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

  本发明涉及以下式子(I)的化合物： 其中r，s，t，Y1-Y2，R1，R2，R3，R4，R5，R6和R7具有定义意义，具有法尼醇转移酶抑制活性；它们的制备、含有它们的组合物以及它们作为药物的用途。