3-(1H-benzoimidazol-2-yl)-7-dimethylamino-chromen-2-one | 53350-29-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(1H-benzoimidazol-2-yl)-7-dimethylamino-chromen-2-one
• 英文别名: 3-(1H-benzimidazol-2-yl)-7-(dimethylamino)chromen-2-one
• CAS: 53350-29-1
• 化学式: C₁₈H₁₅N₃O₂
• 分子量: 305.336
• InChiKey: OQRCWBYIXJBYJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COUMARINES USEFUL AS BIOMARKERS<br/>[FR] COUMARINES CONVENANT COMME BIOMARQUEURS
  申请人：NOVARTIS AG

  公开号：WO2003074519A1

  公开（公告）日：2003-09-12

  The invention provides compounds of formula (I), wherein R, R1, R2, R3 and R4 are as defined in the description, and their preparation. The compounds of formula I are useful as biomarkers.

  该发明提供了式（I）的化合物，其中R、R1、R2、R3和R4如描述中所定义，以及它们的制备。式I的化合物可用作生物标志物。
• AQUEOUS DISPERSION OF COLORED PARTICLES
  申请人：MITSUBISHI PENCIL COMPANY, LIMITED

  公开号：US20210071006A1

  公开（公告）日：2021-03-11

  Provided is an aqueous dispersion of colored particles suitable for colorants for writing instrument inks, inkjet inks, painting materials, aqueous coatings, and the like. The aqueous dispersion of colored particles includes a polymer having at least a unit of a monomer derived from a dye having a polymerizable unsaturated group. The monomer derived from the dye is preferably derived from the compound represented by General Formula (1) below: where Dye represents a dye residue, R 1 represents a hydrogen atom or a methyl group, Y 2 represents —O— or —NR 10 —, where R 10 represents a hydrogen atom or an alkyl group, A 1 represents an alkylene group which is unsubstituted or substituted by at least one group selected from —OCO—, —COO—, —NHCONH—, and the like in the chain thereof and/or at the terminal thereof, and/or a hydroxy group.

  提供一种适用于书写工具墨水、喷墨墨水、绘画材料、水性涂料等颜色颜料的水性彩色颗粒分散液。彩色颗粒的水性分散液包括至少具有源自具有可聚合不饱和基团的染料的单体的聚合物。源自染料的单体最好源自下面的一般式（1）所表示的化合物：其中Dye代表染料残基，R1代表氢原子或甲基基团，Y2代表—O—或—NR10—，其中R10代表氢原子或烷基基团，A1代表未经取代或通过至少选择自—OCO—、—COO—、—NHCONH—等群之一取代的烷基基团以及/或在链中和/或末端具有一个羟基的亚烷基基团。
• Coumarines useful as biomarkers
  申请人：Auberson Yves

  公开号：US20050169837A1

  公开（公告）日：2005-08-04

  The invention provides compounds of formula (I), wherein R, R 1 , R 2 , R 3 and R 4 are as defined in the description, and their preparation. The compounds of formula I are useful as biomarkers.

  本发明提供了式(I)的化合物，其中R、R1、R2、R3和R4如描述中所定义，并提供它们的制备方法。式(I)的化合物可用作生物标志物。
• COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
  申请人：PTC Therapeutics Inc.

  公开号：US20150119380A1

  公开（公告）日：2015-04-30

  Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

  本文提供了用于治疗脊髓性肌萎缩症的化合物、其组合物及与其一起使用的用途。在一个具体实施例中，本文提供了一种可以用来调节SMN2基因转录的mRNA中包含外显子7的形式化合物。在另一个具体实施例中，本文提供了一种可以用来调节SMN1基因转录的mRNA中包含外显子7的形式化合物。在另一个实施例中，本文提供了一种可以用来调节SMN1和SMN2基因转录的mRNA中包含外显子7的形式化合物。
• COLORED PARTICLE AQUEOUS DISPERSION
  申请人：MITSUBISHI PENCIL COMPANY, LIMITED

  公开号：EP3725854A1

  公开（公告）日：2020-10-21

  Provided is an aqueous dispersion of colored particles being excellent in water resistance and light resistance, which is suitable for colorants for writing instrument inks, inkjet inks, painting materials, aqueous coatings, and the like. The aqueous dispersion of colored particls includes a polymer having at least a unit of a monomer derived from a dye having a polymerizable unsaturated group. The monomer derived from the dye is preferably derived from the compound represented by General Formula (1) below: where Dye represents a dye residue, R1 represents a hydrogen atom or a methyl group, Y2 represents -O- or -NR10-, where R10 represents a hydrogen atom or an alkyl group, A1 represents an alkylene group having at least one group selected from -OCO-, -COO-, -NHCONH-, and the like in the chain thereof and/or at the terminal thereof; an alkylene group having at least one group selected from -OCO-, -COO-, and -NHCONH- in the chain thereof and/or at the terminal thereof, and also has a hydroxy group as a substituent; an alkylene group which has a hydroxy group as a substituent; or an alkylene group} .

  本发明提供了一种耐水性和耐光性极佳的有色微粒水性分散体，它适用于书写工具墨水、喷墨墨水、绘画材料、水性涂料等的着色剂。有色微粒的水性分散体包括一种聚合物，其中至少有一个单元的单体来自具有可聚合不饱和基团的染料。衍生自染料的单体最好衍生自下式（1）所代表的化合物： 其中染料代表染料残基，R1 代表氢原子或甲基、 Y2 代表-O-或-NR10-，其中 R10 代表氢原子或烷基、 A1 代表亚烷基，其链上和/或其末端至少有一个选自-OCO-、-COO-、-NHCONH-等的基团；亚烷基，其链上和/或其末端至少有一个选自-OCO-、-COO-和-NHCONH-的基团，同时具有羟基作为取代基；具有羟基作为取代基的亚烷基；或亚烷基}。