4-nitro-1,3,5,7-tetraphenyl-heptane-1,7-dione | 63877-69-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 4-nitro-1,3,5,7-tetraphenyl-heptane-1,7-dione
• 英文别名: 4-Nitro-1,3,5,7-tetraphenyl-heptan-1,7-dion；4-Nitro-1,7-dioxo-1,3,5,7-tetraphenyl-heptan；4-Nitro-1,3,5,7-tetraphenylheptane-1,7-dione
• CAS: 63877-69-0
• 化学式: C₃₁H₂₇NO₄
• 分子量: 477.56
• InChiKey: SBZQETAJBOAVFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  80
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硝基甲烷 、 苯亚甲基苯乙酮 在 potassium fluoride 作用下， 以 乙醇 为溶剂， 生成 4-nitro-1,3,5,7-tetraphenyl-heptane-1,7-dione
  参考文献：
  名称：

  Ostaszynski,A. et al., Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1964, vol. 12, p. 1 - 8

  摘要：

  DOI：

文献信息

• Asymmetric induction in the Michael reaction by means of chiral phase-transfer catalysts derived from cinchona and ephedra alkaloids
  作者：Stefano Colonna、Alberto Re、Hans Wynberg

  DOI：10.1039/p19810000547

  日期：——

  Asymmetric induction in the Michael reaction has been achieved using alkaloidonium salts in a two-phase system with optical yields of up to 36 and 26% in the addition to αβ-unsaturated ketones of thiols and nitroalkanes respectively. The presence of a hydroxy-group β to the 'onium function is essential to achieve substantial asymmetric syntheses.

  在生物碱的两相体系中，除了分别添加硫醇和硝基烷烃的αβ-不饱和酮外，在两相系统中使用生物碱盐的光学收率分别高达36％和26％，从而实现了迈克尔反应中的不对称诱导。on官能团的羟基β的存在对于实现基本的不对称合成是必不可少的。
• Reactions of Nitroparaffins. I. Synthesis and Reduction of Some γ-Nitroketones
  作者：Milton C. Kloetzel

  DOI：10.1021/ja01202a010

  日期：1947.10
• Alcoholic Ammonia as a Reagent for Nitro Compounds and Unsaturated Ketones
  作者：David E. Worrall、Cyril J. Bradway

  DOI：10.1021/ja01300a029

  日期：1936.9
• Microwave solvent-free synthesis of nitrocyclohexanols
  作者：Olivier Correc、Karine Guillou、Jack Hamelin、Ludovic Paquin、Françoise Texier-Boullet、Loı̈c Toupet

  DOI：10.1016/j.tetlet.2003.10.148

  日期：2004.1

  New nitrocyclohexanols 3a-f are synthesized by a clean and original method from nitromethane 1 and unsaturated ketones 2a-f in the presence of solid potassium fluoride-alumina under solvent-free conditions coupled with microwave irradiation. The reaction involves a double and diastereoselective Michael addition followed by ring closure. Another diastereomer 3', which differs by the configuration of C-4, is obtained in the presence of piperidine and EtOH at room temperature. (C) 2003 Elsevier Ltd. All rights reserved.
• 157. 2 : 4-Diarylpyrroles. Part II. Methines
  作者：Maurice A. Thorold Rogers

  DOI：10.1039/jr9430000596

  日期：——