4-(4-(4-methoxy-6-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)morpholine | 1347759-06-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(4-(4-methoxy-6-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)morpholine
• 英文别名: 4-[4-(4-methoxy-6-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl]morpholine
• CAS: 1347759-06-1
• 化学式: C₁₇H₁₉N₅O₂
• 分子量: 325.37
• InChiKey: FXVFHGDVQBDOQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-chloro-3-iodo-6-methyl-1-trityl-1H-pyrazolo[4,3-c]pyridine 在 二氯双[二叔丁基-(4-二甲基氨基苯基)膦]钯(II) 三乙基硅烷 、 potassium acetate 、 sodium carbonate 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 2.75h， 生成 4-(4-(4-methoxy-6-methyl-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-yl)morpholine
  参考文献：
  名称：

  [EN] PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2
  [FR] PYRAZOLOPYRIDINES EN TANT QU'INHIBITEURS DE LA KINASE LRRK2

  摘要：

  一种具有化学式la或化学式lb的化合物，或其在药学上可接受的盐或酯，其中R1选择自：芳基；杂环芳基；-NHR3；融合芳基-C4-7-杂环烷基；-CONR4R5；-NHCOR6；-C3-7-环烷基；-0-C3-7-环烷基；-NR3R6；以及可选择地取代的-C1-6烷基；其中所述的芳基、杂环芳基、融合芳基-C4-7-杂环烷基和C4-7-杂环烷基均可选择地取代；Q选择自CN、卤素，或选择自C1-6-烷基、C3-7-环烷基、杂环烷基、芳基和杂环芳基，每种均可选择地取代一个或多个取代基A；R2选择自氢、芳基、C1-6-烷基、C2-6-烯烃基、C3-7-环烷基、杂环芳基、C4-7-杂环烷基和卤素，其中所述的C1-6-烷基、C2-6-烯烃基、芳基、杂环芳基和C4-7-杂环烷基均可选择地取代；R3选择自芳基、杂环芳基、C4-7-杂环烷基、C3-7-环烷基、融合芳基-C-杂环烷基和C1-6-烷基，每种均可选择地取代；R4和R5各自独立地为氢，或可选择地取代的C3-7-环烷基、芳基、杂环芳基、C1-6-烷基或C3-6-杂环烷基；或R4和R5与其连接的N一起形成一个C3-6-杂环烷基环；每个R6独立地选择自C1-6-烷基、C3-7-环烷基、C-杂环烷基、芳基和杂环芳基，每种均可选择地取代；每个R7选择自氢、可选择地取代的C1-6-烷基和C3-7-环烷基；每个R8和R9各自独立地为氢或可选择地取代的C1-6-烷基；或R8和R9与其连接的N一起形成一个C4-6-杂环烷基；每个R10选择自C3-7-环烷基和可选择地取代的C1-6-烷基；每个R11独立地选择自C1-6-烷基、C3-7-环烷基、C1-6-烷基-C3-7-环烷基、C4-7-杂环烷基、芳基和杂环芳基，每种均可选择地取代；A选择自卤素、-NR4S02R5、-CN、-OR6、-NR4R5、-NR7R11、羟基、-CF3、-CONR4R5、-NR4COR5、-NR7(CO)NR4R5、-N02、-C02H、-C02R6、-S02R6、-S02NR4R5、-NR4COR5、-NR4COOR5、6-烷基和-COR6。进一步涉及到具有化学式la和lb的化合物的制药组合物、治疗用途和制备过程。

  公开号：

  WO2011141756A1

文献信息

• [EN] PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2<br/>[FR] PYRAZOLOPYRIDINES COMME INHIBITEURS DE LA KINASE LRRK2
  申请人：MEDICAL RES COUNCIL TECHNOLOGY

  公开号：WO2012038743A1

  公开（公告）日：2012-03-29

  The present invention relates to compounds of formula I, or pharmaceutically acceptable salts or esters thereof, (Formula I) wherein R1 is selected from: aryl; heteroaryl; -NHR3; fused aryl-C4_7-heterocycloalkyl; -CONR4R5; - NHCOR6; -C3-7-cycloalkyl,-NR3R6; -OR3; OH; NR4R5; and alkyl optionally substituted with a substituent selected from R11 and a group A; wherein said aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7- heterocycloalkyi are each optionally substituted with one or more substituents selected from C1-6-alkyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl, aryl and a group A, and said C1-6-alkyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl, and aryl substituents are in turn each optionally substituted with one or more groups selected from R11 and a group A; R2 is selected from hydrogen, aryl, C1-6-alkyl, C2-6-alkenyl, C3-7-cycloalkyl, heteroaryl, heterocycloalkyi, fused aryl-C4-7-rheterocycloalkyl and halogen, wherein said C1-6-alkyl, C2-6-alkenyl, aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7-heterocycloalkyl are each optionally substituted with one or more substituents selected from R11 and A. Further aspects relate to pharmaceutical compositions and therapeutic uses of said compounds.

  本发明涉及式I的化合物，或其药学上可接受的盐或酯，其中R1选自：芳基；杂环芳基；-NHR3；融合芳基-C4_7-杂环烷基；-CONR4R5；-NHCOR6；-C3-7-环烷基，-NR3R6；-OR3；OH；NR4R5；和烷基，可选择地被来自R11和A组的取代基取代；其中所述的芳基，杂环芳基，融合芳基-C4-7-杂环烷基和C4-7-杂环烷基可分别被来自C1-6-烷基，C3-7-环烷基，杂环芳基，C4-7-杂环烷基，芳基和A组的一个或多个取代基取代，而所述的C1-6-烷基，C3-7-环烷基，杂环芳基，C4-7-杂环烷基和芳基取代基又可分别被来自R11和A组的一个或多个基团取代；R2选自氢，芳基，C1-6-烷基，C2-6-烯基，C3-7-环烷基，杂环芳基，杂环烷基，融合芳基-C4-7-杂环烷基和卤素，其中所述的C1-6-烷基，C2-6-烯基，芳基，杂环芳基，融合芳基-C4-7-杂环烷基和C4-7-杂环烷基可分别被来自R11和A的一个或多个取代基取代。进一步方面涉及所述化合物的药物组合物和治疗用途。
• COMPOUNDS
  申请人：CHAN Bryan K.

  公开号：US20120295883A1

  公开（公告）日：2012-11-22

  The present invention relates to substituted pyrazolopyridine compounds, and pharmaceutically acceptable salts or esters thereof. The present invention further relates to therapeutic uses of pharmaceutical compositions comprising the substituted pyrazolopyridine compounds, for example, in cancer and neurodegenerative diseases.

  本发明涉及取代的吡唑吡啶化合物，以及其药学上可接受的盐或酯。本发明还涉及包括所述取代的吡唑吡啶化合物的药物组合物的治疗用途，例如用于癌症和神经退行性疾病。
• PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2
  申请人：Chan Brayn

  公开号：US20130267513A1

  公开（公告）日：2013-10-10

  A compound of formula Ia or formula Ib, or a pharmaceutically acceptable salt or ester thereof, wherein R 1 is selected from: aryl; heteroaryl; —NHR 3 ; fused aryl-C 4-7 -heterocycloalkyl; —CONR 4 R 5 ; —NHCOR 6 ; —C 3-7 -cycloalkyl; -0-C 3-7 -cycloalkyl; —NR 3 R 6 ; and optionally substituted —C 1-6 alkyl; wherein said aryl, heteroaryl, fused aryl-C 4-7 -heterocycloalkyl and C 4-7 -heterocycloalkyl are each optionally substituted; Q is CN, halogen, or is selected from C 1-6 -alkyl, C 3-7 -cycloalkyl, heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted with one or more substituents A; R 2 is selected from hydrogen, aryl, C 1-6 -alkyl, C 2-6 -alkenyl, C 3-7 -cycloalkyl, heteroaryl, C 4-7 -heterocycloalkyl and halogen, wherein said C 1-6 -alkyl, Cz-B-alkenyl, aryl, heteroaryl and C 4-7 -heterocycloalkyl are each optionally substituted; R 3 is selected from aryl, heteroaryl, C 4-7 -heterocycloalkyl, C 3-7 -cycloalkyl, fused aryl-C-heterocycloalkyl and C 1-6 -alkyl, each of which is optionally substituted; R 4 and R 5 are each independently hydrogen, or optionally substituted C 3-7 -cycloalkyl, aryl, heteroaryl, C 1-6 -alkyl or C 3-6 -heterocycloalkyl; or R 4 and R 5 together with the N to which they are attached form a C 3-6 -heterocycloalkyl ring; each R 6 is independently selected from C 1-6 -alkyl, C 3-7 -cycloalkyl, C-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; each R 7 is selected from hydrogen, optionally substituted C 1-6 -alkyl and C 3-7 -cycloalkyl; each of R 8 and R 9 is independently hydrogen or optionally substituted C 1-6 -alkyl; or R 8 and R 9 together with the N to which they are attached form a C 4-6 -heterocycloalkyl; each R 10 is selected from C 3-7 -cycloalkyl and optionally substituted C 1-6 -alkyl; each R 11 is independently selected from C 1-6 -alkyl, C 3-7 -cycloalkyl, C 1-6 -alkyl-C 3-7 -cycloalkyl, C 4-7 -heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; A is selected from halogen, —NR 4 S0 2 R 5 , —CN, —OR 6 , —NR 4 R 5 , —NR 7 R 11 , hydroxyl, —CF 3 , —CONR 4 R 5 , —NR 4 COR 5 , —NR 7 (CO)NR 4 R 5 , —N0 2 , —C0 2 H, —C0 2 R 6 , —S0 2 R 6 , —S0 2 NR 4 R 5 , —NR 4 COR 5 , —NR 4 COOR 5 , 6 -alkyl and —COR 6 . Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formulae Ia and Ib.

  公式Ia或公式Ib的化合物，或其药学上可接受的盐或酯，其中R1选自：芳基；杂环芳基；-NHR3；融合芳基-C4-7-杂环烷基；-CONR4R5；-NHCOR6；-C3-7-环烷基；-0-C3-7-环烷基；-NR3R6；和可选取代的-C1-6烷基；其中所述的芳基、杂环芳基、融合芳基-C4-7-杂环烷基和C4-7-杂环烷基均可选取代基；Q为CN、卤素，或选自C1-6烷基、C3-7-环烷基、杂环烷基、芳基和杂环芳基，每种基均可选取代基A；R2选自氢、芳基、C1-6烷基、C2-6烯基、C3-7-环烷基、杂环芳基、C4-7-杂环烷基和卤素，其中所述的C1-6烷基、C2-6烯基、芳基、杂环芳基和C4-7-杂环烷基均可选取代基；R3选自芳基、杂环芳基、C4-7-杂环烷基、C3-7-环烷基、融合芳基-C-杂环烷基和C1-6烷基，每种基均可选取代基；R4和R5各自独立地为氢，或可选取代的C3-7-环烷基、芳基、杂环芳基、C1-6烷基或C3-6-杂环烷基；或R4和R5与它们连接的N一起形成C3-6-杂环烷基环；每个R6各自选自C1-6烷基、C3-7-环烷基、C-杂环烷基、芳基和杂环芳基，每种基均可选取代基；每个R7选自氢、可选取代的C1-6烷基和C3-7-环烷基；每个R8和R9各自独立地为氢或可选取代的C1-6烷基；或R8和R9与它们连接的N一起形成C4-6-杂环烷基；每个R10选自C3-7-环烷基和可选取代的C1-6烷基；每个R11各自独立地选自C1-6烷基、C3-7-环烷基、C1-6-烷基-C3-7-环烷基、C4-7-杂环烷基、芳基和杂环芳基，每种基均可选取代基；A选自卤素、-NR4S02R5、-CN、-OR6、-NR4R5、-NR7R11、羟基、-CF3、-CONR4R5、-NR4COR5、-NR7(CO)NR4R5、-N02、-C02H、-C02R6、-S02R6、-S02NR4R5、-NR4COR5、-NR4COOR5、6-烷基和-COR6。此外，还涉及公式Ia和Ib的化合物的制备过程、药物组合物和治疗用途。
• US8569281B2
  申请人：——

  公开号：US8569281B2

  公开（公告）日：2013-10-29