(S)-5-(3-sec-butoxy-5-(5-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide | 1352570-22-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-5-(3-sec-butoxy-5-(5-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide
• 英文别名: 5-[3-[(2S)-butan-2-yl]oxy-5-(5-methyl-6-oxo-1H-pyrimidin-2-yl)phenoxy]-N,N-dimethylpyrimidine-2-carboxamide
• CAS: 1352570-22-9
• 化学式: C₂₂H₂₅N₅O₄
• 分子量: 423.472
• InChiKey: NGKVMIABGKKISZ-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE
  申请人：PFIZER

  公开号：WO2011158149A1

  公开（公告）日：2011-12-22

  O N NH R3 R2 O R1 168 ABSTRACT The present invention provides a 2-(3,5-disubstitutedphenyl)pyrimidin- 4(3H)-one compound of Formula (I) 5 (I) or a pharmaceutically acceptable salt thereof wherein R 1, R2 and R3 are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and 10 the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.

  本发明提供了一种Formula (I)的2-(3,5-二取代苯基)嘧啶-4(3H)-酮化合物或其药学上可接受的盐，其中R1、R2和R3如本文所定义。已发现Formula (I)的化合物可作为葡萄糖激酶激活剂。因此，Formula (I)的化合物及其药物组成物对于治疗由葡萄糖激酶介导的疾病、紊乱或症状是有用的。