(5-氯-1H-苯并[D]咪唑-2-基)甲胺二盐酸盐 | 1185297-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: (5-氯-1H-苯并[D]咪唑-2-基)甲胺二盐酸盐
• 英文名称: (5-chloro-1H-benzo[d]imidazol-2-yl)methanamine dihydrochloride
• 英文别名: (6-chloro-1H-benzimidazol-2-yl)methanamine;dihydrochloride
• CAS: 1185297-00-0
• 化学式: C8H10Cl3N3
• 分子量: 254.5
• InChiKey: CGQMTBSKRULBBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.52
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.7
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• [EN] BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSES DE BENZIMIDAZOLE UTILISES COMME ANTAGONISTES DU RECEPTEUR DE LA VITRONECTINE
  申请人：SCHERING CORP

  公开号：WO2000032578A1

  公开（公告）日：2000-06-08

  The present invention provides compounds having formula (I) wherein n, p, q and r are each independently selected from 0 or 1; a, b, c, and d each independently represents a carbon or nitrogen atom, with the proviso that no more than two of a, b, c, and d are nitrogen atoms; Y and Y' each independently represents 1-4 optional substituents selected from alkyl, alkoxy, halo, -CF3, and -C(O)OH; R?1, R2, R3 and R4¿ are H or specified substituents; R?5, R6, R7, R8, R9, R10, R11 and R12¿ are independently selected from H or C¿1?-C3 alkyl; or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof. Also provided are methods of using these compounds for treating vitronectin-mediated disorders, e.g., cancer, retinopathy, artherosclerosis, vascular restenosis, and osteoporosis.

  本发明提供具有式(I)的化合物，其中n，p，q和r各自独立地选自0或1；a，b，c和d各自独立地表示碳或氮原子，但a，b，c和d中不超过两个是氮原子；Y和Y'各自独立地表示从烷基，烷氧基，卤素，-CF3和-C（O）OH中选择的1-4个可选取代基；R?1，R2，R3和R4¿为H或指定的取代基；R?5，R6，R7，R8，R9，R10，R11和R12¿各自独立地选自H或C¿1?-C3烷基；或其生物可降解酯或其药学上可接受的盐。还提供使用这些化合物治疗玻璃蛋白酶介导的疾病的方法，例如癌症，视网膜病变，动脉粥样硬化，血管再狭窄和骨质疏松症。
• Chemical compounds as antibiotics
  申请人：Antabio SAS

  公开号：US11000511B2

  公开（公告）日：2021-05-11

  The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

  本发明涉及一种化合物，它是符合式 (I) 的茚满衍生物，或其药学上可接受的盐，[式 (I)] 其中 R1、R2、R3、n、R4、p、q、L、X 和 m 如本文所定义。这些化合物可作为单独的抗生素或与其他抗生素联合使用，用于治疗抗菌感染。这些化合物还可用于体外治疗，例如清洁组合物。
• BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS
  申请人：SCHERING CORPORATION

  公开号：EP1135374B9

  公开（公告）日：2007-02-21
• CHEMICAL COMPOUNDS AS ANTIBIOTICS
  申请人：ANTABIO SAS

  公开号：US20200155509A1

  公开（公告）日：2020-05-21

  The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R 1 , R 2 , R 3 , n, R 4 , p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.
• US6204282B1
  申请人：——

  公开号：US6204282B1

  公开（公告）日：2001-03-20