tert-butyl 4-hydroxy-3,4-dihydro-2H-pyridine-1-carboxylate | 643759-64-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tert-butyl 4-hydroxy-3,4-dihydro-2H-pyridine-1-carboxylate
• 英文别名: 4-Hydroxy-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
• CAS: 643759-64-2
• 化学式: C₁₀H₁₇NO₃
• 分子量: 199.25
• InChiKey: SWXJUNRMZFARMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-hydroxy-3,4-dihydro-2H-pyridine-1-carboxylate 在 四丙基高钌酸铵 、 diethylzinc 、 N-甲基吗啉氧化物 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 14.0h， 生成 tert-butyl 5-oxo-2-azabicyclo[4.1.0]heptane-2-carboxylate
  参考文献：
  名称：

  [EN] COMPOUNDS AS GLP-1R AGONISTS
  [FR] COMPOSÉS À UTILISER EN TANT QU'AGONISTES DE GLP-1R

  摘要：

  The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions containing such compounds, or pharmaceutically acceptable salts thereof. Methods of preparing these compounds and compositions, and methods of using these compounds and compositions to treat or prevent a disease or a condition mediated by GLP-1R, are also provided.

  公开号：

  WO2023164050A1
• 作为产物：
  描述：

  1-Boc-3,4-环氧哌啶 在 正丁基锂 作用下， 以 乙醚 为溶剂， 以34 %的产率得到tert-butyl 4-hydroxy-3,4-dihydro-2H-pyridine-1-carboxylate
  参考文献：
  名称：

  [EN] COMPOUNDS AS GLP-1R AGONISTS
  [FR] COMPOSÉS À UTILISER EN TANT QU'AGONISTES DE GLP-1R

  摘要：

  The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions containing such compounds, or pharmaceutically acceptable salts thereof. Methods of preparing these compounds and compositions, and methods of using these compounds and compositions to treat or prevent a disease or a condition mediated by GLP-1R, are also provided.

  公开号：

  WO2023164050A1

文献信息

• Organolithium-induced synthesis of acyclic unsaturated amino alcohols from epoxides of dihydropyrroles and tetrahydropyridines
  作者：David M Hodgson、Timothy J Miles、Jason Witherington

  DOI：10.1016/j.tet.2003.10.010

  日期：2003.12

  The alkylative double ring-opening of Bus-protected 2,5-dihydropyrrole epoxides 13 and 29 with organolithiums to give 3-substituted 1-aminobut-3-en-2-ols 13-19 and 30-32 are described. Bus-protected tetrahydropyridine epoxide 38 reacts with organolithiums to give 4-substituted 1-aminobut-4-en-3-ols 39 and tetrahydropyridinol 40. (C) 2003 Elsevier Ltd. All rights reserved.