(4aR,5R,9bR)-7,8-Dimethoxy-1-methyl-5-phenyl-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one | 81202-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (4aR,5R,9bR)-7,8-Dimethoxy-1-methyl-5-phenyl-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one
• 英文别名: (4aR,5R,9bR)-7,8-dimethoxy-1-methyl-5-phenyl-4,4a,5,9b-tetrahydro-3H-indeno[1,2-b]pyridin-2-one
• CAS: 81202-69-9
• 化学式: C₂₁H₂₃NO₃
• 分子量: 337.419
• InChiKey: JADHGORTVTXKFX-PUCZYUMASA-N

反应信息

• 作为反应物：
  描述：

  (4aR,5R,9bR)-7,8-Dimethoxy-1-methyl-5-phenyl-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one 在 lithium aluminium tetrahydride 作用下， 生成 (4aS,5S,9bS)-7,8-Dimethoxy-1-methyl-5-phenyl-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridine
  参考文献：
  名称：

  2,3,4,4a,5,9b-Hexahydro-1H-indeno[1,2-b]pyridines: potential antidepressants

  摘要：

  The synthesis of various diastereoisomeric H4a,H5-cis,H4a,H9b-cis- and H4a,H5-trans,H4a,H9b-cis-2,3,4,4a,5,9b-hexahydro -1H-indeno[1,2-b]pyridines is described, as well as the evaluation of their antidepressant potency. Elucidation of structure-activity relationships revealed the H4a,H5-trans compounds as being by far the more active of the two series of diastereoisomers. Pharmacological and biochemical data suggest that these compounds are potential antidepressants with central stimulating properties, which are characterized by strong norepinephrine and dopamine reuptake inhibition.

  DOI：

  10.1021/jm00370a004
• 作为产物：
  描述：

  (4aS,5S,9bS)-7,8-dimethoxy-5-phenyl-1,3,4,4a,5,9b-hexahydroindeno[1,2-b]pyridin-2-one 、 碘甲烷 在 sodium amide 作用下， 生成 (4aR,5R,9bR)-7,8-Dimethoxy-1-methyl-5-phenyl-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one
  参考文献：
  名称：

  Kunstmann, Rudolf; Lerch, Ulrich; Wagner, Konrad, Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1437 - 1444

  摘要：

  DOI：