[2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-[2-(2-iodo-4,5-methylenedioxyphenyl)ethyl]amine | 809233-35-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: [2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-[2-(2-iodo-4,5-methylenedioxyphenyl)ethyl]amine
• 英文别名: [2-(1,4-Dioxaspiro[4.5]dec-6-yl)ethyl][2-(2-iodo-4,5-methylenedioxyphenyl)ethyl]amine；2-(1,4-dioxaspiro[4.5]decan-6-yl)-N-[2-(6-iodo-1,3-benzodioxol-5-yl)ethyl]ethanamine
• CAS: 809233-35-0
• 化学式: C₁₉H₂₆INO₄
• 分子量: 459.324
• InChiKey: VNQLSXWZRBRKJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-[2-(2-iodo-4,5-methylenedioxyphenyl)ethyl]amine 在 盐酸 、 异丙基氯化镁 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 cis-15,16-Methylendioxyerythrinan
  参考文献：
  名称：

  An Improved Stereocontrolled Route to cis-Erythrinanes by Combined Intramolecular Strecker and Bruylants Reaction

  摘要：

  Condensation of (2-iodophenyl)ethylamines with cyclohexanoylacetaldehyde provided the corresponding aldimines which were reduced yielding secondary phenethylcyclohexanoylethylamines. These in turn were appropriate intermediates to prepare several erythrinanes by a sequential intramolecular Strecker and intramolecular Bruylants reaction. In contrast, the C-ring homologue schelhammeranes were not available on this route.

  DOI：

  10.1007/s00706-004-0184-8
• 作为产物：
  描述：

  (1,4-dioxaspiro[4.5]dec-6-yl)acetaldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 4.0h， 生成 [2-(1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-[2-(2-iodo-4,5-methylenedioxyphenyl)ethyl]amine
  参考文献：
  名称：

  An Improved Stereocontrolled Route to cis-Erythrinanes by Combined Intramolecular Strecker and Bruylants Reaction

  摘要：

  Condensation of (2-iodophenyl)ethylamines with cyclohexanoylacetaldehyde provided the corresponding aldimines which were reduced yielding secondary phenethylcyclohexanoylethylamines. These in turn were appropriate intermediates to prepare several erythrinanes by a sequential intramolecular Strecker and intramolecular Bruylants reaction. In contrast, the C-ring homologue schelhammeranes were not available on this route.

  DOI：

  10.1007/s00706-004-0184-8