N-phenyl-N-thiazol-2-yl-acetamide | 116055-40-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-N-thiazol-2-yl-acetamide
• 英文别名: N-Phenyl-N-thiazol-2-yl-acetamid；N-phenyl-N-(1,3-thiazol-2-yl)acetamide
• CAS: 116055-40-4
• 化学式: C₁₁H₁₀N₂OS
• 分子量: 218.279
• InChiKey: KBAMTODQYRKRJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-苯基-1,3-噻唑-2-胺 、 乙酸酐 在 sodium acetate 作用下， 生成 N-phenyl-N-thiazol-2-yl-acetamide
  参考文献：
  名称：

  Postowskii; Lundina, Zhurnal Obshchei Khimii, 1959, vol. 29, p. 608,611, 614; engl. Ausg. S. 604, 606, 609

  摘要：

  DOI：

文献信息

• Tetrahydro-2H-thiopyran-4-carboxamide derivative
  申请人：Kontani Toru

  公开号：US20050032855A1

  公开（公告）日：2005-02-10

  A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.

  一种制药药物，特别是一种新型化合物，用于预防或治疗涉及Herpesviridae家族病毒感染的各种疾病，特别是各种单纯疱疹病毒感染，如水痘（水痘）通过水痘-带状疱疹病毒，水痘-带状疱疹通过潜伏水痘-带状疱疹病毒的复发感染，唇疱疹和脑炎疱疹通过HSV-1以及生殖器疱疹通过HSV-2感染。N-2-[(4-取代苯基)氨基]-2-氧乙基}四氢-2H-噻吩-4-羧酰胺衍生物，其中苯基在位置4被特定的五元或六元杂环基取代，具有如此强大的抗病毒活性，以至于以低剂量口服治疗这些疾病。
• Phenylacetamido-thiazole derivatives, process for the preparation and their use as antitumor agents
  申请人：——

  公开号：US20040235919A1

  公开（公告）日：2004-11-25

  Compounds represented by formula (I), as defined in the description, wherein R is a hydrogen atom or a methyl group and R1 is a group as defined in the specification, or a pharmaceutically acceptable salt thereof, are disclosed; the said compounds are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.

  公式(I)所代表的化合物，如描述中所定义，其中R是氢原子或甲基基团，R1是规范中定义的基团，或其药用盐，均已披露；所述化合物在治疗细胞增殖紊乱疾病（如癌症）方面具有用途，与细胞周期依赖性激酶活性异常有关。
• Amide derivative
  申请人：——

  公开号：US20040034232A1

  公开（公告）日：2004-02-19

  The invention relates to a novel amide derivative which is an N-({[4-(substituted thiazol-4-yl)phenyl]carbamoyl}methyl)amide derivative having a characteristic in that an aryl or heteroaryl group as an aromatic ring group is directly substituted on the N atom of amido group. Since said amide derivative has excellent anti-herpesvirus action, it is useful as medicaments and antiviral agents, particularly as preventive or therapeutic agents for various diseases accompanied by Herpesviridae virus infections, illustratively, varicella (chickenpox) accompanied by varicella zoster virus infection, shingles accompanied by the recurrent infection of latent varicella zoster virus, labial herpes and herpes encephalitis accompanied by HSV-1 infection, genital herpes accompanied by HSV-2 and the like various herpesvirus infections.

  本发明涉及一种新型酰胺衍生物，其为一种N-({[4-(取代噻唑-4-基)苯基]氨基甲酰}甲基)酰胺衍生物，其特征在于，芳基或杂环芳基作为芳香环基直接取代在酰胺基的N原子上。由于该酰胺衍生物具有出色的抗疱疹病毒作用，因此它可用作药物和抗病毒剂，特别是用作各种伴随疱疹病毒感染的疾病的预防或治疗剂，例如伴随带状疱疹病毒感染的水痘（鸡痘）、伴随潜伏带状疱疹病毒的复发感染的带状疱疹、伴随HSV-1感染的唇疱疹和脑炎疱疹、伴随HSV-2的生殖器疱疹以及各种其他疱疹病毒感染。
• Amide derivatives
  申请人：Kontani Toru

  公开号：US20060229295A1

  公开（公告）日：2006-10-12

  There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. An N-2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.

  提供了一种药物，特别是一种新型化合物，可用于预防或治疗涉及疱疹病毒家族感染的各种疾病，特别是各种疱疹病毒感染，如水痘（通过水痘带状疱疹病毒）、带状疱疹（通过潜伏水痘带状疱疹病毒的复发感染）、单纯疱疹病毒性口唇炎和单纯疱疹病毒性脑炎（通过HSV-1）以及生殖器疱疹（通过HSV-2感染）。一种N-2-[(4-取代苯基)氨基]-2-氧乙基}四氢-2H-硫吡喃-4-羧酰胺衍生物，其中苯基在4位被特定的5-或6-成员杂环基取代，以及其盐具有有效的抗病毒活性，其口服低剂量治疗上述疾病。
• MEDICAMENT FOR GENITAL HERPES
  申请人：Suzuki Hiroshi

  公开号：US20090030049A1

  公开（公告）日：2009-01-29

  [PROBLEMS] To provide a medicament useful for the treatment of genital herpes after the development of lesions. [MEANS FOR SOLVING PROBLEMS] An N-[2-[(4-substituted phenyl)amino]-2-oxoethyl]tetrahydro-2H-thiopyran-4-carboxamide derivative in which the phenyl group is substituted at position 4 by a specific 5- or 6-membered heteroaryl group has an excellent anti-herpesvirus effect and can exert excellent therapeutic effect on genital herpes after the development of lesions. Therefore, the compound is useful for the treatment of genital herpes after the development of lesions.

  【问题】提供一种在生殖器疱疹发展后有用的药物治疗。【解决问题的方法】一种N-[2-[(4-取代苯基)氨基]-2-氧乙基]四氢-2H-噻吩-4-羧酰胺衍生物，其中苯基在4位被特定的5-或6-成员杂环基取代，具有出色的抗疱疹病毒效果，并且可以在生殖器疱疹发展后表现出优异的治疗效果。因此，该化合物对于治疗生殖器疱疹发展后的病变非常有用。