5,6-(trimethylene)-pyridin-2-one-4-carboxylic acid | 115122-79-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5,6-(trimethylene)-pyridin-2-one-4-carboxylic acid
• 英文别名: 2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-4-carboxylicacid；2-Oxo-2,5,6,7-tetrahydro-1h-cyclopenta[b]pyridine-4-carboxylic acid；2-oxo-1,5,6,7-tetrahydrocyclopenta[b]pyridine-4-carboxylic acid
• CAS: 115122-79-7
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: VJWZPFRDVGCOOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,6-(trimethylene)-pyridin-2-one-4-carboxylic acid 在 氯化亚砜 作用下， 反应 1.0h， 生成 2-Oxo-1,5,6,7-tetrahydrocyclopenta[b]pyridine-4-carbonyl chloride
  参考文献：
  名称：

  Lowe, John A.; Ewing, Frank E.; Drozda, Susan E., Synthetic Communications, 1989, vol. 19, # 17, p. 3027 - 3036

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl 3-cyano-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-4-carboxylate 在 硫酸 作用下， 反应 20.0h， 以70%的产率得到5,6-(trimethylene)-pyridin-2-one-4-carboxylic acid
  参考文献：
  名称：

  Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents

  摘要：

  A series of fused and functionalized pyridine derivatives were designed, synthesized and tested for their potential antitubercular properties. All these novel compounds were prepared by using multistep methods involving the construction of pyridine ring as a key synthetic step. Some of these compounds were found to be interesting when tested for their antitubercular properties in vitro and one of them appeared as an attractive and potential antitubercular agent. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.05.096

文献信息

• [EN] GLUCOSE TRANSPORT INHIBITORS<br/>[FR] INHIBITEURS DE TRANSPORT DU GLUCOSE
  申请人：BAYER PHARMA AG

  公开号：WO2016202898A1

  公开（公告）日：2016-12-22

  The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

  本发明涉及选择性抑制葡萄糖转运蛋白1（GLUT1）的化合物，涉及制备该类化合物的方法，涉及包含该类化合物的药物组合物和药物组合物，涉及利用该类化合物制造用于治疗或预防疾病的药物组合物，以及用于制备该类化合物的中间化合物。
• Quinuclidine derivatives
  申请人：Pfizer Inc

  公开号：US05422354A1

  公开（公告）日：1995-06-06

  Quinuclidine derivatives of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein m, P, Z, Y, R.sup.1, R.sup.2 and R.sup.3 are as defined below. The compounds are substance P antagonists and, therefore, are useful in treating gastrointestinal disorders, central nervous system disorders, inflammatory diseases, pain and migraine.

  公式为##STR1##的喹胺衍生物及其药用盐，其中m、P、Z、Y、R.sup.1、R.sup.2和R.sup.3的定义如下。这些化合物是P物质拮抗剂，因此可用于治疗胃肠道疾病、中枢神经系统疾病、炎症性疾病、疼痛和偏头痛。
• Libermann et al., Bulletin de la Societe Chimique de France, 1958, p. 687,691
  作者：Libermann et al.

  DOI：——

  日期：——
• WO2008/63625
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis and pharmacological activity of substituted amides of 2-chloro- and 2-arylamino-5,6-tri(tetra)methyleneisonicotinic acids
  作者：T. A. Smirnova、M. Yu. Gavrilov、F. Ya. Nazmetdinov、L. P. Drovosekova、M. E. Kon'shin、V. E. Kolla

  DOI：10.1007/bf02508449

  日期：1999.3